Drucktoleranztest des Sehnervenkopfes bei okulärer Hypertension

Le, Pillunat; Stodtmeister, Richard; Wilmanns, I.; Christ, Th.

doi:10.1055/s-2008-1050570

Cited by 13 publications

(1 citation statement)

References 4 publications

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“…As previously pointed out [Pillunat et al, 1985a, b;1986] healthy subjects show a dif ferent pressure susceptibility of the optic nerve head from glaucoma patients. While the VER/pressure curves in healthy subjects show an intermittent plateau of a constant VER amplitude in spite of further increasing TOP the VER/pressure curves in glaucoma patients sinks during pressure elevation near ly linearly down to the noise level.…”

Section: Discussionmentioning

confidence: 49%

Effect of Timolol on Optic Nerve Head Autoregulation

Pillunat¹,

Stodtmeister²,

Wilmanns³

et al. 1986

Ophthalmologica

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Healthy subjects show, in a special pressure compliance test of the optic nerve head, signs of autoregulation of optic nerve head circulation. In this test visual evoked response (VER) amplitudes were recorded during stepwise increased intraocular pressures. In the resulting VER amplitude/pressure curves glaucoma patients did not show the sign of autoregulation of optic nerve head circulation which is seen in healthy subjects. It is known that topically applied timolol maleate may affect optic nerve head circulation. Therefore the pressure compliance test was performed in 20 healthy eyes before and after 3 days of topically applied timolol maleate 0.5%. The aim of the study was to test the effect of topically applied timolol on optic nerve head autoregulation. In addition we determined the ocular perfusion pressures, heart rate and mean arterial blood pressure. While the ocular perfusion pressures show a slight, but statistically not significant, decrease under timolol, the systemic parameters and the autoregulation behavior did not change.

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Section: Discussionmentioning

confidence: 49%