Drug accumulation and elimination in Calliphora vicina larvae

Sadler, David; Fuke, Chiaki; Court, F.; Pounder, Derrick J.

doi:10.1016/0379-0738(94)01663-1

Cited by 74 publications

(56 citation statements)

References 5 publications

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“…A amostragem de insetos, variada entre pupas e larvas, constitui fator de elevada mobilidade na detecção das drogas (GOSSELIN et al, 2011). Diversos autores (SADLER et al, 1995;TRACQUI et al, 2004;CARVALHO, 2010), em estudos variados, descobriram que a coleta em diferentes lugares do corpo era muito importante, devido às mudanças de concentrações por causa das propriedades físico-químicas do fárma-co, quando esse entra em contato com órgão e tecidos diferentes, logo, alterando a concentração nos insetos. Quando feita a coleta das espécies no local do crime, é preciso realizar procedimento adequado para a preservação do espécime.…”

Section: Metodologiaunclassified

Uso dos diptera na análise entomotoxicológica e na estimativa do intervalo pós-morte (IPM)

et al. 2015

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Section: Metodologiaunclassified

Uso dos diptera na análise entomotoxicológica e na estimativa do intervalo pós-morte (IPM)

et al. 2015

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“…Following the work of Beyer et al [9], demonstrating the presence of phenobarbital in larvae found on a skeletonised female body, numerous experiments were carried out by other groups [10,11,12,13,14,15,16,20,21,23,24] to detect controlled substances and drugs (e.g. opiates, benzodiazepines, antidepressants, cocaine, acetylsalicylic acid and amphetamine derivatives) and to gain useful information on the cause of death, when the toxicologist was unable to examine the usual biological fluids and tissues.…”

Section: Drugs In Larvaementioning

confidence: 99%

“…In 1980, the first article about a drug, phenobarbital, was published by Beyer et al [9]. In entomological cases, other authors have also analysed drugs and narcotics, in particular triazolam, oxazepam, phenobarbital, alimemazine, clomipramine [10], bromazepam, levomepromazine and clomipramine [11], morphine and phenobarbital [12], cocaine [13,14], amitriptyline, propoxyphene and acetaminophen [15], opiates [16,17,18,19], amitriptyline and nortriptyline [20,21,22], amitriptyline, temazepam, trazodone and trimipramine [23], salicylates, paracetamol, aminohippurate, amphetamines and barbiturates [24], and amphetamine derivatives [25].…”

Section: Introductionmentioning

confidence: 98%

The detection of toxic substances in entomological specimens

Candela¹,

Aventaggiato²

2001

International Journal of Legal Medicine

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Entomotoxicology (the study of drugs in insects), a new field of forensic investigations, has still to be precisely defined especially with respect to the toxic substances that can be assessed in entomological specimens. The aim of the present work was to review the relevant entomological publications in order to analyse and describe the various toxic substances that have been detected in biological specimens. Experimental studies have been reviewed separately from case reports. Toxic substances have been classified according to forensic toxicology methodology and on the basis of the chemical and analytical features. This classification will help investigators to identify the compounds that can be found in such biological samples and may stimulate new analytical research investigations. Given the heterogeneity of specimens, the use of non-specific tests (such as immunoenzyme assays) is not recommended and specific and sensitive techniques are suggested. Methods such as GC-MS and HPLC-MS allow the exact identification of the toxic substances and their metabolites.

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“…5 In cases of advanced decomposition, when no tissues or body fluids are available, C. vicina and other Calliphoridae can serve as alternate specimens for toxicological analysis. [6][7][8] Also, C. vicina larvae are known agents of traumatic myiasis in man and animals. 4 In Europe this diptera plays a minor role in secondary sheep myiasis.…”

Section: Discussionmentioning

confidence: 99%

Case report: recovery of Calliphora vicina first-instar larvae from a human traumatic wound associated with a progressive necrotizing bacterial infection.

Delhaès¹,

Bourel²,

Scala³

et al. 2001

Am J Trop Med Hyg

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Abstract. Human myiasis caused by Calliphora vicina is rare in Europe. Here we report a case of C. vicina infection occurring in the traumatic leg wound of a healthy 21-year-old man. Firstly, a progressive necrotizing infection developed in the wound despite administration of antibiotics. Aeromonas hydrophila was isolated from the wound samples. Secondly, during debridement, C. vicina first-instar larvae were isolated from the wound. To our knowledge, this is the first European case of C. vicina wound myiasis associated with severe A. hydrophila infection.Human myiasis is due to parasitic infestation of human body by larvae of the fly Brachycere Diptera, commonly known as maggots. In Europe, Calliphora vicina RobineauDesvoidy (Diptera: Calliphoridae) is a very common urban species of fly closely associated with man.

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Drug accumulation and elimination in Calliphora vicina larvae

Cited by 74 publications

References 5 publications

Uso dos diptera na análise entomotoxicológica e na estimativa do intervalo pós-morte (IPM)

Uso dos diptera na análise entomotoxicológica e na estimativa do intervalo pós-morte (IPM)

The detection of toxic substances in entomological specimens

Case report: recovery of Calliphora vicina first-instar larvae from a human traumatic wound associated with a progressive necrotizing bacterial infection.

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