Background: Information on the pattern of acute poisonings in Birjand hospitals is limited. This study aimed to address this knowledge gap by examining the admissions in a poisoning center in Birjand. Methods: Medical records of a main poisoning center in Birjand were reviewed for poisoned patients admitted to hospital from September 2017 to August 2018.Results: During the study period 897 cases of acute poisoning were evaluated. Patients’ age ranged from 11 to 97 years, with a high rate of poisonings between 15 and 25 years. A slight female predominance in poisoning cases was observed. Most cases of poisonings occurred in spring, and the common route of exposure was oral (90.7%). High incidence of poisoning occurred in married couples, uneducated patients, and residents of urban areas. Patients with a previous medical history experienced addiction and psychiatric disorders. Intentional poisoning accounted for 49.5% of acute poisoning cases referred to the hospital in the current study. The main groups of toxicants were pharmaceutical products (45.8%), chemicals (13.3%), and narcotics (9.4%). The mean of hospital stay was 2.8±3.0 days, and the final treatment outcome was 66.0% complete recovery. The mortality rate was 0.8%, and most cases of death were due to pesticides poisoning.Conclusions: Acute poisoning, particularly intentional poisoning, is common in Iran. Due to the high rate of deliberate poisonings, especially in young adults and students, monitoring drugs and distribution and exceptional attention to mental health should be seriously taken into consideration by national health authorities for the prevention of suicide attempts.