Drug addiction co-morbidity with alcohol: Neurobiological insights

McGinn, M. Adrienne; Pantazis, Caroline B.; Tunstall, Brendan J.; Marchette, Renata C.N.; Carlson, Erika R.; Said, Nadia; Koob, George F.; Vendruscolo, Leandro F.

doi:10.1016/bs.irn.2020.11.002

Cited by 5 publications

(4 citation statements)

References 414 publications

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“…All sequence data has been deposited in a publically accessible database, with serial number PRJNA867698. 2…”

Section: S Rrna Gene Sequencing Analysismentioning

confidence: 99%

“…It is well known that alcohol consumption is a risk factor for a variety of health problems. Currently, most research has concentrated on metabolism, neurotransmitters, neuroimaging, and the effect of alcohol use on neuronal functioning in the brain ( 2 ). However, the pathophysiology of AUD remains unknown, and there is a paucity of neurobiological markers to diagnose and forecast the risk of AUD, as well as new therapy targets and directions.…”

Section: Introductionmentioning

confidence: 99%

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The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Gong

et al. 2022

Front. Psychiatry

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IntroductionAlcohol use disorder (AUD) has evolved into a severe social and medical issue. However, the exact environmental factors triggering AUD pathophysiology remain unknown. A growing body of research has shown that environmental elements can affect the brain via the microbiota-gut-brain axis.MethodsWe employed 16S rRNA gene sequencing technology to investigate the composition and diversity of intestinal microbiota in 32 AUD males and 35 healthy controls (HCs), as well as its relationship on cognitive function.ResultsOur findings showed that the alpha diversity indices in AUDs were much lower than HCs. The abundances of Faecalibacterium, Gemmiger, Lachnospiracea_incertae_sedis, Megamonas, and Escherichia were significantly different between AUD and HC groups and could be used as a basis for judging whether excessive drinking. The abundances of Faecalibacterium, Gemmiger, Escherichia, and Fusobacterium can be used to judge the cognitive function of the population.ConclusionThese data suggested that the gut dysbiosis in AUD patients, and some specific microbiota were considered to be related to alcohol intake and cognitive function. This study provides important information for further study of the pathogenesis of AUD from the perspective of intestinal microbiota.

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“…All sequence data has been deposited in a publically accessible database, with serial number PRJNA867698. 2…”

Section: S Rrna Gene Sequencing Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Gong

et al. 2022

Front. Psychiatry

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“…Indeed, the role of central stress hormone and neuropeptide signaling in response to stress has emerged as a conceptual bridge between chronic substance use, affective and cognitive disruption, and propensity to relapse. 89 As the key integrative link between the systemic and central brain stress response, the hypothalamic-pituitary-adrenal (HPA) axis is responsible for orchestrating adaptive processes that return an organism to homeostasis following exposure to a stressor. Release of corticotropin-releasing factor (CRF) from the hypothalamus initiates this process by regulating the production and processing of pro-opiomelanocortin from the anterior pituitary.…”

Section: Brain Stress Signaling In Affective Pain and Sudmentioning

confidence: 99%

The Convergent Neuroscience of Affective Pain and Substance Use Disorder

Pahng

Edwards

2021

ARCR

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Opioids and alcohol are widely used to relieve pain, with their analgesic efficacy stemming from rapid actions on both spinal and supraspinal nociceptive centers. As an extension of these relationships, both substances can be misused in attempts to manage negative affective symptoms stemming from chronic pain. Moreover, excessive use of opioids or alcohol facilitates the development of substance use disorder (SUD) as well as hyperalgesia, or enhanced pain sensitivity. Shared neurobiological mechanisms that promote hyperalgesia development in the context of SUD represent viable candidates for therapeutic intervention, with the ideal strategy capable of reducing both excessive substance use as well as pain symptoms simultaneously. Neurocognitive symptoms associated with SUD, ranging from poor risk management to the affective dimension of pain, are likely mediated by altered activities of key anatomical elements that modulate executive and interoceptive functions, including contributions from key frontocortical regions. To aid future discoveries, novel and translationally valid animal models of chronic pain and SUD remain under intense development and continued refinement. With these tools, future research strategies targeting severe SUD should focus on the common neurobiology between negative reinforcement and affective elements of pain, possibly by reducing excessive stress hormone and neurotransmitter activity within shared circuitry.

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“…Chronic alcohol consumption poses a serious public health problem in the United States and worldwide. An estimated 8.6% Americans remain addicted to alcohol or drugs and there are 15 million new cases of alcohol use disorder (AUD) each year in the US alone, representing an economic burden of nearly a quarter of a trillion dollars [ 1 , 2 ]. The frequency of drinking has been accelerated during the COVID-19 pandemic [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

et al. 2021

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Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences depends, among other things, on the endocannabinoid system. We have analyzed the relative role of central vs. peripheral cannabinoid CB1 receptors (CB1R) using a “two-bottle” as well as a “drinking in the dark” paradigm in mice. The globally acting CB1R antagonist rimonabant and the non-brain penetrant CB1R antagonist JD5037 inhibited voluntary alcohol intake upon systemic but not upon intracerebroventricular administration in doses that elicited anxiogenic-like behavior and blocked CB1R-induced hypothermia and catalepsy. The peripherally restricted hybrid CB1R antagonist/iNOS inhibitor S-MRI-1867 was also effective in reducing alcohol consumption after oral gavage, while its R enantiomer (CB1R inactive/iNOS inhibitor) was not. The two MRI-1867 enantiomers were equally effective in inhibiting an alcohol-induced increase in portal blood endotoxin concentration that was caused by increased gut permeability. We conclude that (i) activation of peripheral CB1R plays a dominant role in promoting alcohol intake and (ii) the iNOS inhibitory function of MRI-1867 helps in mitigating the alcohol-induced increase in endotoxemia.

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Drug addiction co-morbidity with alcohol: Neurobiological insights

Cited by 5 publications

References 414 publications

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

The Convergent Neuroscience of Affective Pain and Substance Use Disorder

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

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