Drug Administration

Hauff, Peter; Nebendahl, Klaus

doi:10.1007/978-3-319-42202-2_8

Cited by 1 publication

(2 citation statements)

References 51 publications

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“…The local ethic committee (IAEC) approval is necessary before commencing any route of administration procedure in rodents for a test substance 1 .…”

Section: Routes Of Administration and Injection Techniquesmentioning

confidence: 99%

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2023

IJPSR

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Preclinical drug or pharmaceutical research in mouse and rat species is inevitable in the scientific investigations of a chemical substance or lead entity. The administration routes are the experimental study design, and regulatory requirements may influence the study of humans' intended therapeutic/clinical route. Specific route selection in the investigation of test substances must be profoundly well-versed to the research scientists and approved by local ethics committee members. Every route has advantages and disadvantages in absorption, bioavailability, metabolism, and distribution of substances, which should be carefully considered while selecting a route. Routes of administration can be performed painlessly if proper heed is given to the restraint and holding of animals and using adequate technical skills by technical persons and research scientists. This review describes the principal and common routes used in early drug discovery programs and preclinical research, including guidelines for safe injection volumes, sites of administration, preparation of sites, advantages & disadvantages, limitations, handling and restraint techniques, vehicle selection, and formulation strategies. Conclusion: This can be concluded knowledge of available methods for administration and handling techniques and the disposition pattern as well as formulation strategies will aid the scientist in choosing the most suitable route for the compound to be investigated. INTRODUCTION:Scientific investigation of the test substance or lead molecule in rodents, particularly mouse and rat species, is indispensable in preclinical pharmaceutical research or biomedical research 1 . Test substance administration in rodents is one of the major methods for evaluating biological activity.

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“…The local ethic committee (IAEC) approval is necessary before commencing any route of administration procedure in rodents for a test substance 1 .…”

Section: Routes Of Administration and Injection Techniquesmentioning

confidence: 99%

“…In biomedical or preclinical research, the mouse and rat are the common and frequently used species 1 . Various routes are employed to investigate the biological activity of test substances in solutions/suspensions form.…”

Section: And Conclusionmentioning

confidence: 99%

Untitled

2023

IJPSR

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show abstract

Drug Administration

Cited by 1 publication

References 51 publications

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