Drug and nutrient administration on the NICU – is delivery during breastfeeding an alternative to oral syringes?

Maier, T.; Bonner, Oliver; Peirce, Paula; Slater, Nigel K.H.; Beardsall, Kathryn

doi:10.1016/j.jnn.2019.09.009

Cited by 4 publications

(11 citation statements)

References 15 publications

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“…Twenty-six mother-infant dyads provided their consent, of which twenty dyads completed the full study protocol (Table 1). Reasons for declining participation included: mother felt overwhelmed with the establishment of breastfeeding (3), mother did not wish to have further infant blood samples taken (3), mother declined vitamin administration (1), mother had stopped using a nipple shield (2), no reason provided (8). Reasons for non-completion/exclusion from analysis in the six cases were: change to bottle feeding (1), discharge before study feed (2), blood sampling time not kept (2), and parent-led withdrawal (1).…”

Section: Resultsmentioning

confidence: 99%

“…[3,4] Qualitative studies within our Neonatal Unit also demonstrated parents' and nursing staff's support for such an intervention, indicating that it could help foster mother-infant bonding and encourage parental empowerment. [2] The study aimed to evaluate the feasibility and acceptability of solid formulation delivery to infants while breastfeeding. Following previous lab-based and qualitative research, it is the first clinical feasibility study to ever be undertaken with mother-infant dyads.…”

Section: Introductionmentioning

confidence: 99%

“…[1] In low-resource settings, additional challenges of liquid formulations arise due to the lack of refrigerated storage. [2] To address this shortcoming, research at the University of Cambridge’s Department of Paediatrics and Department of Chemical Engineering and Biotechnology has been exploring alternative approaches to therapeutic delivery in infancy. In-vitro studies have previously demonstrated the potential of drug administration using a breastfeeding simulation apparatus.…”

Section: Introductionmentioning

confidence: 99%

“…[3,4] Qualitative studies within our Neonatal Unit also demonstrated parents’ and nursing staff’s support for such an intervention, indicating that it could help foster mother-infant bonding and encourage parental empowerment. [2]…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic delivery from a solid formulation during breastfeeding: a feasibility study

Maier

Peirce

Baird

et al. 2020

Preprint

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Background: Enteral drug and nutrient delivery to breastfed infants depends on the use of oral syringes and liquid formulations. This can pose both practical and emotional challenges to drug delivery. Objectives: The presented study aimed to explore the potential of using solid formulations for therapeutic delivery during breastfeeding. Methods: Single centre feasibility study within a tertiary level neonatal unit in the UK, involving twenty-six breastfeeding mother-infant dyads. Vitamin B12 was delivered to infants during breastfeeding from a solid formulation within a commercial silicon nipple shield. Outcomes included the quantitative measurement of change in serum vitamin B12 and a mixed methods assessment of maternal expectations and experiences. Results: Participants described the surprising ease of 'drug' delivery, with no negative impact on breastfeeding behaviour or sensation reported. Vitamin B12 levels rose on average from a baseline of 533 pg/mL (236 - 925 pg/mL) to 1871 pg/mL (610 - 4981 pg/mL) at 6 - 8 hours post-delivery. All mothers expressed their support for this approach, 85% a preference over the use of oral syringes. Reasoning for support related to the reduced medicalisation of this procedure compared to the use of oral syringes, and a desire for choices in relation to their infants' health. Conclusions: This study demonstrated that therapeutic delivery from a solid formulation within a nipple shield was feasible and acceptable to mothers and infants.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic delivery from a solid formulation during breastfeeding: a feasibility study

Maier

Peirce

Baird

et al. 2020

Preprint

Self Cite

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“…Breastfeeding saves lives, improves health and cuts health costs worldwide. In low-resource settings the delivery of medications, such as de-worming and retrovirals as well as nutrient and mineral supplementation, in liquid formulations is challenging, as liquids need to be refrigerated for storage, and syringes require clean water for sterilization [1]. However recent studies have also highlighted the emotional and practical challenges for many parents, of treating infants with liquid formulations as many infants demonstrate aversive behavior towards drug delivery from oral syringes [2].…”

Section: Introductionmentioning

confidence: 99%

Drug delivery from a solid formulation during breastfeeding—A feasibility study with mothers and infants

et al. 2022

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Background Breastfeeding is critical to health outcomes, particularly in low-resource settings where there is little access to clean water. For infants in their first twelve months of life, the delivery of medications is challenging, and use of oral syringes to deliver liquid formulations can pose both practical and emotional challenges. Objective To explore the potential to deliver medicine to infants via a solid formulation during breastfeeding. Methods Single center feasibility study within a tertiary level neonatal unit in the UK, involving twenty-six breastfeeding mother-infant dyads. A solid formulation of Vitamin B12 was delivered to infants during breastfeeding. Outcomes included the quantitative change in serum vitamin B12 and assessment of maternal expectations and experiences. Results Delivery of Vitamin B12 through a solid formulation that dissolved in human milk did not impair breastfeeding, and Vitamin B12 levels rose in all infants from a mean baseline (range) 533 pg/mL (236–925 pg/mL) to 1871 pg/mL (610–4981 pg/mL) at 6–8 hours post-delivery. Mothers described the surprising ease of ‘drug’ delivery, with 85% reporting a preference over the use of syringes. Conclusions Solid drug formulations can be delivered during breastfeeding and were preferred by mothers over the delivery of liquid formulations via a syringe.

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Fajrin

2024

JHC

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Nutrisi terbaik dalam kualitas dan kuantitas pada saat masa pertumbuhan otak yang terjadi dari 0 bulan sampai 6 bulan terkandung dalam ASI Ekslusif. Cakupan bayi mendapatkan ASI Eksklusif di Pontiaanak mencapai 60,3% dari 2100 bayi usia 0-6 bulan pada tahun 2020. Saigon merupakan Kelurahan yang memiliki cakupan ASI Eksklusif masih rendah yaitu 76 (60%) dari 124 bayi usia 0-6 bulan yang berada di Wilayah Kerja Puskesmas Saigon Pontianak, sehingga perlu dilakukan pembenahan guna memperbaiki hal tersebut. Daun Katuk bermanfaat untuk menstimulasi hormon oksitosin dan prolaktin seperti alkoloid, saponin, polifenol, steroid, dan flavonoid sehingga dapat meningkatkan produksi ASI.

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Drug and nutrient administration on the NICU – is delivery during breastfeeding an alternative to oral syringes?

Cited by 4 publications

References 15 publications

Therapeutic delivery from a solid formulation during breastfeeding: a feasibility study

Therapeutic delivery from a solid formulation during breastfeeding: a feasibility study

Drug delivery from a solid formulation during breastfeeding—A feasibility study with mothers and infants

Penggunaan Modul Edukasi Tentang Peningkatan Produksi ASI Melalui Pemberian Daun Katuk

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