2013
DOI: 10.1111/jcpt.12075
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Drug and nutrition interactions: not just food for thought

Abstract: Summary What is known and objective The management of drug‐drug interactions – from recognition of the interaction potential, to addressing the negative consequences – are well‐recognized and avoided, or rapidly addressed when identified clinically. Drug‐nutrition interactions are no less important than drug‐drug interactions in patient care. Unfortunately, beyond those caused by food, these interactions are less commonly recognized or identified and managed. This article will re‐introduce the topic of drug‐nu… Show more

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Cited by 31 publications
(37 citation statements)
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“…Drug--nutrient interactions result from physical, chemical, physiological or pathophysiological relationships not only between a drug and a nutrient but also between a drug and multiple nutrients, food in general, specific foods or components or nutrition status [55,56]. From a clinical perspective, the interaction could be considered significant if it alters the therapeutic response or compromises nutritional status.…”
Section: Drug--nutrient Interactions 41 Definitionmentioning
confidence: 99%
See 1 more Smart Citation
“…Drug--nutrient interactions result from physical, chemical, physiological or pathophysiological relationships not only between a drug and a nutrient but also between a drug and multiple nutrients, food in general, specific foods or components or nutrition status [55,56]. From a clinical perspective, the interaction could be considered significant if it alters the therapeutic response or compromises nutritional status.…”
Section: Drug--nutrient Interactions 41 Definitionmentioning
confidence: 99%
“…There has been an increased understanding of drug--nutrient interactions and the mechanisms which can influence drug absorption [55,59,60]. As patients with gastric access devices are more prone to these interactions, heightened awareness of recognition and prevention is required among prescribers, pharmacists and drug administrators [56].…”
Section: Specific Drug--nutrient Interactionsmentioning
confidence: 99%
“…However, food–drug interactions may also occur due to changes in the drug's pharmacokinetic and pharmacodynamic and lead to clinically relevant side effects . Recently, Boullata has commented on the potential importance of drug and diet interactions during the management of disease. This article focuses on the assessment of the benefit/risk of a flavonoid‐rich diet during calcineurin inhibitors therapy.…”
Section: What Is Known and Objectivementioning
confidence: 99%
“…The low dietary concentration of flavonoids combined with their poor bioavailability is generally not sufficient to cause FDIs . However, the growing use of herbal extracts and purified flavonoids as dietary supplements may induce sufficiently high concentrations of (unconjugated) flavonoids in the small intestine to cause FDIs . Furthermore, not only the flavonoid aglycones themselves but also their phase‐II metabolites could induce FDIs at various stages of their disposition …”
Section: Introductionmentioning
confidence: 99%
“…[13] However, the growing use of herbal extracts and purified flavonoids as dietary supplements may induce sufficiently high concentrations of (unconjugated) flavonoids in the small intestine to cause FDIs. [14] Furthermore, not only the flavonoid aglycones themselves but also their phase-II metabolites could induce FDIs at various stages of their disposition. [15,16] Quercetin is a major dietary flavonoid notably present in onions, apples, teas or berries [17] (Figure 1b).…”
Section: Introductionmentioning
confidence: 99%