Drug—Biomolecule Interactions: Bioelectrometric Study of the Mechanism of Carbachol Interactions with the Cornea and its Relation to Miotic Activity

Smolenx, Victor F.; Park, Chui S.; Williams, Edward J.

doi:10.1002/jps.2600640344

Cited by 8 publications

(1 citation statement)

References 36 publications

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“…The concentration of CPC used was 0.56 mM (0.020/0) compared to the 2 mM used by Green & Tsnjum (1971), and it was suggested (Mikkelson, Chrai & Robinson 1973) that the concentration difference, together with the difference in technique, was responsible for the alternative interpretation of CPC effects. Other studies (Smolen, Park & Williams 1975) have indicated that drug penetration depends on the fixed charges both within and upon the cornea, and that substances such as benzalkonium chloride affect drug binding sites on the corneal surface.…”

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confidence: 99%

Electrophysiological and Anatomical Effects of Cetylpyridinium Chloride on the Rabbit Cornea

Green

1976

Acta Ophthalmologica

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T h e effects of cetylpyridinium chloride on the trans-corneal potential difference and the surface anatomy of the cornea have been examined. Concentrations of cetylpyridinium chloride from 0.21 m M to 2 mM were used for either 1 or 2 minute exposure times on the in vitro and in vivo cornea for the electrophysiology studies. T h e potential difference of the in vitro cornea showed a concentration and exposure-time dependent decrease, the in vivo cornea shows a qualitatively similar behaviour although quantitatively less. T h e fall in potential difference is preceeded by a hyperpolarization. T h e scanning electromicroscopy reveals a loss of microvilli and microplicae as well as surface pitting, with some exposure of cells underlying the superficial epithelium. These changes occur in a dose-dependent manner. The effect of cetylpyridinium chloride on the cornea is to enhance the permeability of the superficial cells by destroying the cell membranes and causing lysis of the cells. 145Acta ophthal. 54, 2 ion fluxes across the isolated frog skin. Acta physiol. scand. 63, 337-384.

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confidence: 99%