Drug Carriers: Stimuli‐Responsive Nucleic Acid‐Based Polyacrylamide Hydrogel‐Coated Metal–Organic Framework Nanoparticles for Controlled Drug Release (Adv. Funct. Mater. 8/2018)

Chen, Wei‐Hai; Liao, Weizhi; Sohn, Yang Sung; Fadeev, Michael; Cecconello, Alessandro; Nechushtai, Rachel; Willner, Itamar

doi:10.1002/adfm.201870053

Cited by 17 publications

(25 citation statements)

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“…D) Schematic illustration of a detection method based on QDs combined with RCA [142a] . E) MOF with azido groups on surface [150] . F) MOF with amino groups on surface [150] .…”

Section: Nanomaterials That Can Bind To Fnasmentioning

confidence: 99%

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Functional Nucleic Acid Nanomaterials: Development, Properties, and Applications

et al. 2020

Angew Chem Int Ed

149

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www.angewandte.org gami, [6] and other types of unconventional nucleic acids (Figure 1), [3c, 7] that can replace traditional proteases and antibodies, possess independent structural functions, and perform specific biological non-genetic functions. [3a-c, 4a,b, 8] The concept of FNA was also used to generalize the nongenetic functions of nucleic acids (Figure 1). [9] Meanwhile, research on the combination and functions of FNAs, such as DNAzymes, aptazymes, and aptamers, and nanomaterials, Wentao Xu studied at China Agricultural University (BS 2001, PhD 2006) and conducted postdoctoral research there before joining the faculty. He is currently an associate professor in the College of Food Science and Nutritional Engineering at China Agricultural University. His research interest is functional nucleic acid biosensors and nanomaterials. Wanchong He obtained his BS degree from Huazhong Agricultural University in 2017. He is now a PhD candidate in the College of Food Science and Nutritional Engineering at China Agricultural University. His research interest is functional nucleic acid biosensors.

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“…D) Schematic illustration of a detection method based on QDs combined with RCA [142a] . E) MOF with azido groups on surface [150] . F) MOF with amino groups on surface [150] .…”

Section: Nanomaterials That Can Bind To Fnasmentioning

confidence: 99%

“…E) MOF with azido groups on surface [150] . F) MOF with amino groups on surface [150] . G) Schematic illustration and characterization of the encapsulation and unblocking process of a dye/drug loaded MOF [72] .…”

Section: Nanomaterials That Can Bind To Fnasmentioning

confidence: 99%

Functional Nucleic Acid Nanomaterials: Development, Properties, and Applications

et al. 2020

Angew Chem Int Ed

149

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“… Typischer Entstehungsprozess und Elektronenmikroskopiebilder einer FNA‐Nanomaterial‐Heterojunction [162] …”

Section: Wechselwirkungen Zwischen Fnas Und Nanomaterialienunclassified

“…D) Detektionsmethode für QDs in Kombination mit RCA [154a] . E) MOF mit Azidogruppen auf der Oberfläche [162] . F) MOF mit Aminogruppen auf der Oberfläche [162] .…”

Section: Bindung Von Nanomaterialien Mit Fnasunclassified

Funktionelle Nukleinsäure‐Nanomaterialien: Entwicklung, Eigenschaften und Anwendungen

et al. 2020

Angewandte Chemie

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Die Nanotechnologie funktioneller Nukleinsäuren (FNAs) ist ein interdisziplinäres Gebiet, das sich auf die Untersuchung der Wechselwirkungen zwischen FNAs und Nanomaterialien konzentriert und die speziellen Vorteile und Anwendungen von FNA‐Nanomaterialien erforscht. Mit dem Ziel, Biomaterialen der nächsten Generation aufzubauen, die die Vorteile von FNAs und Nanomaterialien kombinieren, haben sich die Wechselwirkungen zwischen FNAs und Nanomaterialien sowie Technologien zur Selbstorganisation von FNAs als wichtige Forschungsgebiete etabliert. Es besteht die Aussicht, dass Targeterkennung, Responsivität und Selbstorganisationsfähigkeit in Kombination mit plasmonischen Eigenschaften, Stabilität, Stimuliresponsivität und Transportfähigkeit verschiedener Nanomaterialien eine Vielzahl an neuartigen faszinierenden Anwendungen erschließen können. Die Forschungen an den strukturellen und funktionellen Eigenschaften von FNAs schreiten rasch voran, und viele Laboratorien haben über zahlreiche Methoden zur Herstellung von FNA‐Nanomaterialien berichtet. In diesem Aufsatz stellen wir zunächst einige weit verbreitete FNAs und Nanomaterialien vor, einschließlich ihrer Klassifizierung, Struktur und Anwendungen, und erläutern die erfolgreichsten Methoden zur Herstellung hochentwickelter FNA‐Nanomaterialien. Des Weiteren diskutieren wir die umfangreichen Anwendungen von FNA‐Nanomaterialien in den Bereichen Bioimaging, Biosensorik und Biomedizin und erläutern unsere Sichtweise der verbliebenen Herausforderungen und Entwicklungstrends.

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“…Hydrogels, identified as soft and wet materials containing a large amount of water in their three‐dimensional networks, have been widely applied in the fields of controlled drug release carriers, tissue engineering scaffolds and biosensors due to their unique features, such as biocompatibility, biodegradability, water retention and adhesive behavior. As is known, stimuli‐responsive polymer hydrogels have been widely applied as tunable drug delivery systems for drug release readily modulated by various stimuli .…”

Section: Introductionmentioning

confidence: 99%

Thermal and pH dual‐responsive hydrogels based on semi‐interpenetrating network of poly(N‐isopropylacrylamide) and collagen nanofibrils

Ding

Zhang

et al. 2019

Polymer International

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Hydrogels with environment-sensitive properties have great potential applications in the controlled drug release field. In this paper, hybrid hydrogels with semi-interpenetrating polymer networks (semi-IPNs), composed of poly(N-isopropylacrylamide) (PNIPAM) as the thermo-sensitive component by in situ polymerization and self-assembled collagen nanofibrils as the pH-sensitive framework, were prepared for controlled release of methyl violet as a model drug. From Fourier transform infrared spectroscopy and scanning electron microscopy, it was indicated that the crosslinking of PNIPAM in the presence of collagen nanofibrils led to the formation of semi-IPNs with homogeneous porous structure, and the semi-IPNs showed improved thermal stability and elastic properties compared with the native collagen as determined using differential scanning calorimetry and rheologic measurements. Furthermore, the semi-IPNs possessed swelling behaviors quite different from those of neat collagen or PNIPAM hydrogel under various pH values and temperatures. Correspondingly, as expected, the drug release behavior in vitro for semi-IPNs performed variously compared with that for single-component semi-IPNs, which revealed the tunable performance of semi-IPNs for release ability. Finally the thermo-and pH-responsive mechanism of the semi-IPNs was illuminated to provide guidance for the application of the thermo-and pH-sensitive collagen-based hybrid hydrogels in controlled drug delivery systems.

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Drug Carriers: Stimuli‐Responsive Nucleic Acid‐Based Polyacrylamide Hydrogel‐Coated Metal–Organic Framework Nanoparticles for Controlled Drug Release (Adv. Funct. Mater. 8/2018)

Cited by 17 publications

References 0 publications

Functional Nucleic Acid Nanomaterials: Development, Properties, and Applications

Functional Nucleic Acid Nanomaterials: Development, Properties, and Applications

Funktionelle Nukleinsäure‐Nanomaterialien: Entwicklung, Eigenschaften und Anwendungen

Thermal and pH dual‐responsive hydrogels based on semi‐interpenetrating network of poly(N‐isopropylacrylamide) and collagen nanofibrils

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