Drug–clay nanohybrids as sustained delivery systems

Yang, Jae‐Hun; Lee, Ji Hee; Ryu, Hyeon-Ju; Elzatahry, Ahmed A.; ALOthman, Zeid A.; Choy, Jin‐Ho

doi:10.1016/j.clay.2016.01.021

Cited by 105 publications

(43 citation statements)

References 86 publications

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“…Application of clay minerals in drug delivery has been intensively investigated in last two decades due to their advantagenous physico-chemical and functional properties, such as high specific surface area, adsorption, and ion exchange, thixotropy, swelling property, chemical inertness, low toxicity and possibility of surface modification (26)(27)(28). Additionally, clays have been recognized as alternative immunogen support in vaccine formulations due to their ability to increase the stabilization of immunogens that can enable easier administration and protection from proteolysis, and improved thermal and storage performance.…”

Section: Novel Inorganic Nanoadjuvants As Potential Antigen Carriersmentioning

confidence: 99%

Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems

Krajišnik¹,

Ilić²,

Nikolić³

et al. 2019

Arhiv za farmaciju

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In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic progress in inorganic (nano)materials synthesis, structure control and functionalization design has led to a growing interest in innovative adjuvants such as clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems, such as nanoemulsions, in order to protect antigens from premature proteolytic degradation and/or to improve antigen immunogenicity by facilitating antigen uptake and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence, particularly in children population (noninvasive or minimally invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety.

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Section: Novel Inorganic Nanoadjuvants As Potential Antigen Carriersmentioning

confidence: 99%

Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems

Krajišnik¹,

Ilić²,

Nikolić³

et al. 2019

Arhiv za farmaciju

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“…In addition, 2D materials possess unusual electronic, mechanical and optical properties and hence, they can be used as building blocks in a wide range of composites. Concerning the contemporary applications of 2D compounds, they serve as efficient catalysts for water splitting [6][7][8][9][10][11][12][13][14][15] or organic reactions [16][17][18][19][20][21], drug carriers [22][23][24][25][26][27][28][29][30][31], sensors [32][33][34][35][36][37][38][39], materials for energy production and storage [2,15,21,[40][41][42][43][44][45][46][47][48][49] or adsorbers [50]…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

et al. 2020

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Counteracting reactive oxygen species (ROS, e.g., superoxide radical ion, H2O2 and hydroxyl radical) is an important task in fighting against oxidative stress-related illnesses and in improving product quality in industrial manufacturing processes. This review focuses on the recent advances on two-dimensional (2D) nanomaterials of antioxidant activity, which are designed for effective decomposition of ROS and thus, for reduction of oxidative stress. Some materials featured in this paper are of uni- or multi-lamellar structures modified with small molecular or enzymatic antioxidants. Others are enzyme-mimicking synthetic compounds (the so-called nanozymes) prepared without antioxidant additives. However, carbon-based materials will not be included, as they were extensively reviewed in the recent past from similar aspects. Given the landmark development around the 2D materials used in various bio-applications, sheet-like antioxidant compounds are of great interest in the scientific and technological communities. Therefore, the authors hope that this review on the recent progresses will be helpful especially for researchers working on novel developments to substantially reduce oxidative stress either in biological systems or industrial liquors.

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“…The exchanges of Si 4+ by Al 3+ and Al 3+ by Mg 2+ in the silica tetrahedral sheet and alumina octahedral sheet, respectively, generate a net negative charge that is generally neutralized by adsorption of inorganic cations in the interlayer space (Na + , Ca 2+ , K + , and Mg 2+ ). These inorganic cations can be replaced by organic cations, subsequently causing montmorillonite interlayer expansion ascribed to the bigger size of the organic molecules [22,23]. The combination of clay minerals with other organic molecules (either active or not) produce compounds commonly known as nanohybrids.…”

Section: Introductionmentioning

confidence: 99%

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

et al. 2020

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Background: Carvacrol, an essential oil with antimicrobial activity against a wide range of pathogens, and its water soluble carvacrol prodrugs (WSCP1-3) were intercalated into montmorillonite (VHS) interlayers to improve their stability in physiological media and promote their absorption in the intestine. Methods: Intercalation of prodrugs by cation exchange with montmorillonite interlayer counterions was verified by X-ray powder diffraction and confirmed by Fourier transform infrared spectroscopy and thermal analysis. Results: In vitro release studies demonstrated that montmorillonite successfully controlled the release of the adsorbed prodrugs and promoted their bioactivation only in the intestinal tract where carvacrol could develop its maximum antimicrobial activity. The amount of WSCP1, WSCP2, and WSCP3 released from VHS were 38%, 54%, and 45% at acid pH in 120 min, and 65%, 78%, and 44% at pH 6.8 in 240 min, respectively. Conclusions: The resultant hybrids successfully controlled conversion of the prodrugs to carvacrol, avoiding premature degradation of the drug.

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Drug–clay nanohybrids as sustained delivery systems

Cited by 105 publications

References 86 publications

Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems

Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

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