Drug combination therapy of systemic lupus erythematosus

Miescher, P. A.; Favre, H; Lemoine, Robert; Huang, You-Peng

doi:10.1007/bf00197523

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…Clinical benefits obtained by administering cyclosporine in combination with prednisone even in patients whose disease has failed to respond to a previous steroid therapy have been described (10,11), but no controlled trial has been reported fully until now. To compare the effectiveness of cyclosporine and azathioprine in the maintenance therapy of patients with lupus nephritis, we organized a multicenter, prospective, randomized, open, blinded-end point, controlled trial in which patients with active disease initially were treated with an induction therapy and then randomly assigned to low-dose prednisone plus cyclosporine or azathioprine.…”

mentioning

confidence: 99%

A Randomized Pilot Trial Comparing Cyclosporine and Azathioprine for Maintenance Therapy in Diffuse Lupus Nephritis over Four Years

Moroni

Doria

Mosca

et al. 2006

Clinical Journal of the American Society of Nephrology

154

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There is not agreement about the best maintenance treatment for patients with diffuse lupus nephritis. This multicenter, randomized trial compared the safety and efficacy of cyclosporine and azathioprine. Seventy-five patients with diffuse proliferative lupus were given three intravenous methylprednisolone pulses followed by prednisone and oral cyclophosphamide for a median of 90 d. Subsequently, patients were randomly assigned either to cyclosporine or to azathioprine for 2 yr (core study). Treatment continued for up to 4 yr (follow-up study). The primary outcome measure was the incidence of disease flares. Secondary end points were proteinuria per day, creatinine clearance, and adverse effects. Seven flares occurred in the cyclosporine group, and eight occurred in the azathioprine group. At the end of the core study, mean proteinuria decreased from 2.

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mentioning

confidence: 99%

A Randomized Pilot Trial Comparing Cyclosporine and Azathioprine for Maintenance Therapy in Diffuse Lupus Nephritis over Four Years

Moroni

Doria

Mosca

et al. 2006

Clinical Journal of the American Society of Nephrology

154

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“…Good results with this calcineurin inhibitor in association with steroids, cyclophosphamide, and methotrexate have been reported by Miescher et al in patients with lupus nephritis refractory to previous treatment (11). Other papers reported that cyclosporine induced remission in most patients with SLE membranous nephropathy, but relapse of proteinuria was frequent when the drug was withdrawn (12,13).…”

Section: Cyclosporinementioning

confidence: 86%

New Therapies for Lupus Nephritis

Ponticelli

2006

Clinical Journal of the American Society of Nephrology

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“…Fortunately, in our patients we limited the dose from the very beginning to less than 5 mg/kg per day. In combination with low doses of cortisone and MTX [70,71] this dose of CsA showed no or only insignificant signs of toxicity in 192 kidney biopsy specimens. Furthermore, longterm medication (15-20 years) did not lead to impairment of kidney function.…”

Section: Cyclophosphamidementioning

confidence: 92%