Drug Delivery: Hollow Copper Sulfide Nanoparticle‐Mediated Transdermal Drug Delivery (Small 20/2012)

Ramadan, Samy; Guo, Le‐Hang; Li, Yajuan; Yan, Bingfang; Lü, Wei

doi:10.1002/smll.201290110

Cited by 3 publications

(3 citation statements)

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“…Under the chosen conditions the patch can be indeed used for a least a week safely. It has been previously demonstrated that photo-thermal ablation using pulsed rather than continuous laser light produces instant heating, which ceases at the end of each light pulse, resulting in much less temperature increase in the skin and favorable release [55]. In addition, the release profile of ODS under laser pulses of 100 ms, with a dead time of 500 ms, has been examined ( Fig.…”

Section: Release Of Ondansetron (Ods) From Ods Kapton/rgo Patchesmentioning

confidence: 99%

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Teodorescu

Quéniat

Foulon

et al. 2017

Journal of Controlled Release

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The development of a skin-mounted patch capable of controlled transcutaneous delivery of therapeutics through thermal activation provides a unique solution for the controlled release of active principles over long-term periods. Here, we report on a flexible transdermal patch for photothermal triggered release of ondansetron (ODS), a commonly used drug for the treatment of chemotherapy-induced nausea and vomiting and used as model compound here. To achieve this, a dispersion of ODS-loaded reduced graphene oxide (rGO-ODS) nanosheets were deposited onto Kapton to produce a flexible polyimide-based patch. It is demonstrated that ODS loaded Kapton/rGO patches have a high drug delivery performance upon irradiation with a continuous laser beam at 980nm for 10min due to an induced photothermal heating effect. The ability of ODS impregnated Kapton/rGO patches as transdermal delivery scaffolds for ODS across the skin is in addition investigated using porcine ear skin as a model. We show that the cumulative quantity and flux of ODS passing the skin are highly depending on the laser power density used. At 5Wcm irradiation, the ODS flux across pig skin was determined to be 1.6μgcmh comparable to other approaches. The use of tween 20 as skin enhancer could significantly increase the ODS flux to 13.2μgcmh. While the skin penetration enhancement is comparable to that obtained using other well-known permeation enhancers, the actual superiority and interest of the proposed approach is that the Kapton/rGO photoactivatable skin patch can be loaded with any drugs and therapeutics of interest, making the approach extremely versatile. The on demand delivery of drugs upon local laser irradiation and the possibility to reload the interface with the drug makes this new drug administration route very appealing.

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Section: Release Of Ondansetron (Ods) From Ods Kapton/rgo Patchesmentioning

confidence: 99%

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Teodorescu

Quéniat

Foulon

et al. 2017

Journal of Controlled Release

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“…At room temperature, the DOX-loaded Cu 39 S 28 -FA remained loaded at pH 7.4, and only less than 10 % DOX was released in 24 h. In pH 5.0 buffer, DOX was quickly released to 32 % of the original amount in the first 8 h, and ~45% in 24 h. This pH responsive controlled-release property can be attributed to the dissociation of electrostatic interaction between the positively-charged DOX molecules and negatively-charged Cu 39 S 28 -FA HNPs, due to the weak electrostatic interaction of DOX with COO − and the enhanced solubility of DOX under lower pH environment. 40–42 The Cu 39 S 28 -FA HNPs can effectively leak DOX during the blood circulation and increase the delivery efficacy in cancer cells. Moreover, the release profiles at 37 °C was also tested (Figure S5), which was a reflection of actual physiological environment.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Cu₃₉S₂₈ hollow nanopeanuts for in vivo targeted photothermal chemotherapy

Yang

et al. 2017

J. Mater. Chem. B

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Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu39S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR). In particular, the folic acid (FA) can easily conjugate with the synthesized Cu39S28 HNPs without further modification to get a targeted effect. The FA modified Cu39S28 HNPs showed an efficiently targeting effect in vitro and could considerably enhance the tumor-targeting effect more than 10 times in vivo. Moreover, the synthetical hyperthermia and drug release from Cu39S28 HNPs when under 808 nm laser could significantly improve the therapeutic efficacy compared with photothermal or chemotherapy alone both in vitro and in vivo. The histological studies in main organs also proved the well biocompatibility, while the tumor sites were in seriously destruction due to the accumulation of the nanocomposites and the combined photothermal chemo therapy effect. Therefore, the multi-functional nanocomposites is excellent antitumor agents due to their superb therapy effect in breast cancer.

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“…and carbon NPs have been used for TDD because of their advantages of nearinfrared (NIR) absorption, adjustable size, large surface area-to- volume ratio, easy synthesis, and surface functionalization. [92][93][94][95][96] Haine et al demonstrated the feasibility of transdermal delivery of ovalbumin (OVA) and OVA epitope peptides mediated by the photothermal effect of PTET in Au nanorods. 94 Similarly, PTET in hollow CuS NPs developed by Lu's group 97 achieved good results.…”

Section: Ptet In Thermal Ablationmentioning

confidence: 99%

Research progress of physical transdermal enhancement techniques in tumor therapy

Han

Liu

et al. 2023

Chem. Commun.

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Drug Delivery: Hollow Copper Sulfide Nanoparticle‐Mediated Transdermal Drug Delivery (Small 20/2012)

Cited by 3 publications

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Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Multifunctional Cu₃₉S₂₈ hollow nanopeanuts for in vivo targeted photothermal chemotherapy

Research progress of physical transdermal enhancement techniques in tumor therapy

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Drug Delivery: Hollow Copper Sulfide Nanoparticle‐Mediated Transdermal Drug Delivery (Small 20/2012)

Cited by 3 publications

References 0 publications

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Multifunctional Cu39S28 hollow nanopeanuts for in vivo targeted photothermal chemotherapy

Research progress of physical transdermal enhancement techniques in tumor therapy

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Product

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Multifunctional Cu₃₉S₂₈ hollow nanopeanuts for in vivo targeted photothermal chemotherapy