Drug-Delivery Nanoplatform with Synergistic Regulation of Angiogenesis–Osteogenesis Coupling for Promoting Vascularized Bone Regeneration

Li, Yahong; Zhu, Junjin; Zhang, Xin; Li, Yuanyuan; Zhang, Shu; Yang, Linxin; Li, Ruyi; Wan, Qianbing; Pei, Xibo; Chen, Junyu; Wang, Jian

doi:10.1021/acsami.2c23107

Cited by 45 publications

(16 citation statements)

References 58 publications

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“…The results in Figure S2 and Table S2 demonstrated that nano-ZIF8 exhibit a higher absolute value, indicating its superior stability and enhanced suitability for practical applications. The characteristic functional groups of both nano-ZIF-8 and nano-ZnO are consistent with the previous reports. − ,, …”

Section: Resultssupporting

confidence: 92%

“…The characteristic functional groups of both nano-ZIF-8 and nano-ZnO are consistent with the previous reports. [3][4][5][6][7][8][9][10][11][12]36,37 All characterizations demonstrated the successful preparation of nano-ZIF-8 and nano-ZnO. The strict particle size control can also exclude the potential toxicity arising from variations in particle size, which could affect the subsequent experiments.…”

Section: Establishment Of Mice Tail Vein Injection Modelmentioning

confidence: 98%

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Developing a Selection Framework for Zinc Ion-Based Biomaterial Design: Guided by the Biosafety Assessment of ZIF-8 and ZnO

Mao,

Wang,

et al. 2024

ACS Biomater. Sci. Eng.

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In recent years, nanomaterials have gained widespread use in the biomedical field, with ZIF-8 and ZnO emerging as promising candidates due to their remarkable performance in osteogenesis, angiogenesis, and antimicrobial therapy. However, before advancing these nanomaterials for clinical applications, it is imperative to evaluate their biocompatibility. In particular, comparing nanomaterials with similar biomedical functions is crucial for identifying the most suitable nanomaterials for further development and market entry. Our study aimed to compare the biocompatibility of nano-ZIF-8 and nano-ZnO under the same conditions. We found that nano-ZIF-8 exhibited lower toxicity both in vitro and in vivo compared to nano-ZnO. To gain insights into the underlying mechanisms responsible for this difference, we conducted further experiments to investigate lysosome damage, mitochondrial change, and the occurrence of ferroptosis. Additionally, we performed transcriptome sequencing to analyze the expression of relevant genes, thereby providing robust validation for our findings. In summary, our study highlighted the importance of evaluating nanomaterials with similar biomedical effects. Through this comparative study, we have not only shed light on the superior biocompatibility of nano-ZIF-8 over nano-ZnO, but also contributed valuable insights and methodological references for future material screening endeavors. Ultimately, our study served as a stepping stone toward the development of safer and more effective nanomaterials for various biomedical applications.

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Section: Resultssupporting

confidence: 92%

Section: Establishment Of Mice Tail Vein Injection Modelmentioning

confidence: 98%

Developing a Selection Framework for Zinc Ion-Based Biomaterial Design: Guided by the Biosafety Assessment of ZIF-8 and ZnO

Mao,

Wang,

et al. 2024

ACS Biomater. Sci. Eng.

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“…From the aspect of osteogenesis, MOFs can obtain additional bone formation-promotion ability by carrying drugs . The drug loading system is simply and rapidly synthesized through a one-pot synthesis method, and bioactive factors are stored in the hollow structure of MOFs . Cheng et al encapsulated the risedronate (RIS) molecule in ZIF-8 by a one-step synthesis method.…”

Section: Np Carriers For Bone Regenerationmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Xu,

Cui,

Tian

et al. 2024

ACS Biomater. Sci. Eng.

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The treatment of bone defects has been a long-standing challenge in clinical practice. Among the various bone tissue engineering approaches, there has been substantial progress in the development of drug delivery systems based on functional drugs and appropriate carrier materials owing to technological advances in recent years. A large number of materials based on functional nanocarriers have been developed and applied to improve the complex osteogenic microenvironment, including for promoting osteogenic activity, inhibiting osteoclast activity, and exerting certain antibacterial effects. This Review discusses the physicochemical properties, drug loading mechanisms, advantages and disadvantages of nanoparticles (NPs) used for constructing drug delivery systems. In addition, we provide an overview of the osteogenic microenvironment regulation mechanism of drug delivery systems based on nanoparticle (NP) carriers and the construction strategies of drug delivery systems. Finally, the advantages and disadvantages of NP carriers are summarized along with their prospects and future research trends in bone tissue engineering. This Review thus provides advanced strategies for the design and application of drug delivery systems based on NPs in the treatment of bone defects.

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“…182 Similarly, deferoxamine was delivered through ZIF-8 to induce osteogenesis–angiogenesis coupling. 183…”

Section: Application Of Zinc-based Biomaterials In Bone Repair and Re...mentioning

confidence: 99%

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen,

Wang,

Pei

et al. 2023

J. Mater. Chem. B

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Drug-Delivery Nanoplatform with Synergistic Regulation of Angiogenesis–Osteogenesis Coupling for Promoting Vascularized Bone Regeneration

Cited by 45 publications

References 58 publications

Developing a Selection Framework for Zinc Ion-Based Biomaterial Design: Guided by the Biosafety Assessment of ZIF-8 and ZnO

Developing a Selection Framework for Zinc Ion-Based Biomaterial Design: Guided by the Biosafety Assessment of ZIF-8 and ZnO

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

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