Drug Delivery Systems

Ranade, Vasant; Hollinger, Mannfred A.; Cannon, John F.

doi:10.1201/9781420040142

Cited by 41 publications

(52 citation statements)

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“…Furthermore, porous particles with diameters greater than 5 µm in diameter and possessing mass densities less than 0.4 g/cm 3 were inhaled deeply into the lungs and bypassed clearance mechanisms (59).…”

Section: Porous Polymeric Carriersmentioning

confidence: 99%

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Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures; marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (anti-biotics, anti-cancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

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Section: Porous Polymeric Carriersmentioning

confidence: 99%

“…Over the years, drug delivery methods have improved and evolved significantly to enhance patient compliance, drug bioavailability, safety and therapeutic index (3). Advances in routes of administration also impact both drug efficacy and pharmacokinetics (4), and the oral route is the most popular and convenient for patients (5).…”

Section: Introductionmentioning

confidence: 99%

Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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“…The potential application of dendrimers as drug delivery vectors has received much attention in the pharmaceutical field, particularly in the area of oral drug delivery, owing to unique features such as their well-defined structure, nanometer size, polyvalency, narrow polydispersity and structural flexibility [14,15]. Dendrimers have also shown higher stability against enzymatic degradation compared to other carriers such as liposomes or colloidal carriers [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Luteinizing Hormone-Releasing Hormone (LHRH)-Functionalized Mini-Dendrimers

Rafiee¹,

Mansfeld²,

Moyle³

et al. 2013

IJOC

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Luteinizing hormone-releasing hormone (LHRH) is the key regulator of the hypothalamic-pituitary-gonadal (HPG) axis, which is responsible for the development and functioning of the reproductive system. Delivery of a continuous supply of LHRH agonists causes down-regulation of the LHRH receptors, resulting in a marked decrease in androgens in males and estrogens in females. LHRH analogues are widely used in the treatment of various diseases, including prostate and breast cancer, and reproductive disorders, such as infertility and precocious puberty. However, they require parenteral administration, and no oral formulations are currently available. We synthesized two types of LHRH mini-dendrimers using thioether ligation, aiming to enhance the stability and bioavailability of the peptide drug while maintaining its biologically active conformation. These two compounds include a poly-lysine core conjugated to either the C-terminus of LHRH or a D-amino acid in position 6 of the LHRH sequence. The synthesized dendrimers were analysed using dynamic light scattering, and showed particle sizes of 155 and 115 nm, respectively. The nanometer size, well-defined structure and water solubility of these dendritic analogues make them excellent candidates for further exploration in oral peptide drug delivery.

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“…8 A few catalysts have been approved by the U. S. Food and Drug Administration that are used for biomedical applications. [1][2][3][4][5][6][7][8] 2-Methylene-1,3-dioxepane (MDOP), which is among of the cyclic ketone acetals, can polymerized by free radical ringopening method to produce PCL in commonly used radical initiators. MDOP also proceed with 100% ring opening for polymer and easily copolymerize with vinylic monomers such as styrene, N-isopropylacrylamide, methyl acrylate and methyl methacrylate, and so on using AIBN as a thermal radical initiator.…”

mentioning

confidence: 99%

“…[1][2][3][4] Biodegradable aliphatic polyesters are usually synthesized by ring-opening polymerization (ROP) in bulk or in solution. [1][2][3][4][5][6][7] Ionic ring opening polymerization is commonly used to synthesize poly ("-caprolactone) (PCL) which is an aliphatic polyester often used for biomedical applications. Catalysts for ionic ROP are not easily managed due to their sensitivity to water.…”

mentioning

confidence: 99%

Precipitation Polymerization of 2-Methylene-1,3-dioxepane in Supercritical Carbon Dioxide

Kwon

Lee

Bae

et al. 2008

Polym J

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Free radical homopolymerization experiments were conducted with 2-methylene-1,3-dioxepane in supercritical carbon dioxide (scCO 2 ) using a heterogeneous precipitation polymerization method and AIBN as the initiator. We also synthesized copolymers of 2-methylene-1,3-dioxepane with N-vinyl-2-pyrrolidone. The influence of comonomer feed ratios on the yield, glass transition temperature (T g ) and copolymer composition was investigated. The copolymers produced were characterized by 1 H NMR, FT-IR spectroscopy and DSC. Reactivity ratios of comonomer in the initial step of the precipitation copolymerization process were estimated from copolymer composition analysis. In addition, we investigated the effect of reaction temperature on the reactivity ratios and determined that the reactivity ratios slightly increased and that MDOP had a larger deviation of reactivity ratio than that of NVP with the increased temperature. And the fine sub-micron sized copolymer particles containing with various comonomer ratios were prepared by aerosol solvent extraction system (ASES).

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Drug Delivery Systems

Cited by 41 publications

References 0 publications

Porous Inorganic Drug Delivery Systems—a Review

Porous Inorganic Drug Delivery Systems—a Review

Synthesis and Characterization of Luteinizing Hormone-Releasing Hormone (LHRH)-Functionalized Mini-Dendrimers

Precipitation Polymerization of 2-Methylene-1,3-dioxepane in Supercritical Carbon Dioxide

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