Drug delivery systems between metal, liposome, and polymer-based nanomedicine: A review

Hassan, Saad S. M.; Kamel, Ayman H.; Hashem, Heba M.; Bary, E. M. Abdel

doi:10.17628/ecb.2020.9.91-102

Cited by 27 publications

(8 citation statements)

References 38 publications

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“…Orthopedic infection prevention is generally achieved through the use of systemic antibiotics (which is the most common) and local antibiotics [ 92 ]. There have been recent proposals to coat metallic implant surfaces with controlled antibiotic drug delivery systems [ 93 , 94 ]. A number of advantages are associated with these systems, including controlled release rates and the possibility of coating surfaces with selective agents [ 95 ].…”

Section: Most-studied Drug-eluting Systemsmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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Section: Most-studied Drug-eluting Systemsmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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“…pH-sensitive binding senses only the acidity of the cell's endosomal chamber while it is unable to distinguish cancer cells from healthy cells. In this case, the attached drug is released only in response to the enzymes secreted only by cancer cells [190][191][192].…”

Section: Sensitive Binding To Phmentioning

confidence: 99%

Dendrimer for targeted drug delivery and Vaccine and Immunostimulatory: applications and methods

Kianfar

2022

Preprint

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Dendrimers are a new class of branched polymeric materials. They all are originated from a single nucleus and described as macromolecules with a three-dimensional branching structure. Dendrimers exist in the blossoming phase of drug delivery in micro and Nanosystems for local or systemic brain administration. Dendrimers are three-dimensional molecules containing structural symmetry. They include continuously branched molecules comprising a central unit called core along with branching points. In dendrimers, branching points are essential for functioning and deciding branching generations. The more the number of branching points, the more is the generation number. Synthesized dendrimers are classified as polyamidoamine (PAMAM) dendrimers, polylysine dendrimers, carbosilane dendrimers, and phosphorus-containing dendrimers. Some researchers classify dendrimers as polyatomic and polyionic dendrimers. However, polyanionic dendrimers are preferred because of their less toxicity. Polyamidoamine class of dendrimers is popular and most widely used as a result of their reproducibility, safety, biocompatibility, stability, small size, and precision. They contain tertiary amine branches and alkyl diamine core and are polyatomic. Dendrimer enters the cells like neurons and astrocytes through receptor-mediated endocytosis and micropinocytosis. The main advantage of dendrimers is their drug-loading ability within the cavities of dendrimers, which acts as the main site of the encapsulation process. They have wide applications in neurodegenerative disorders such as cerebral palsy, AD, PD, prions disease, and also in central nervous system imaging and diagnosis. Cationic phosphorous-containing dendrimers were found to interact with the aggregation of plaques and tangles. It was reported that sialic acid–conjugated dendrimers can inhibit the hyperphosphorylation of tau tangles at a micromolar concentration, which is lower than soluble sialic acid. PPI and G5 polyamidoamine dendrimers show anti-prion activity in neuroblastoma ScN2 cells. It was recently revealed that conjugation of CY5-labeled free activable cell-penetrating peptides to PAMAM dendrimers can differentiate the tumor and adjacent tissues thus increasing tumor resects in a mouse xenograft model. Researchers suggested that the intravenous route of administration effectively penetrates the central nervous system with wide biodistribution for extended therapy. The toxicity of dendrimers markedly depends on factors such as the number of generations, core, and surface properties. Amino-terminated dendrimers were found to be toxic due to the shielding of internal cationic charge by surface modification. To overcome the toxicity of dendrimers, the generation and conjugation with biocompatible groups like Polyethylene glycol is increased. Biologically, dendrimers are highly biocompatible and have predictable biodistribution and cell membrane interacting characteristics determined by their size and surface charge. Dendrimers have optimal characteristics to fill the need for efficient immunostimulating compounds (adjuvants) to increase the efficiency of vaccines. The reason is that dendrimers can provide molecularly defined multivalent scaffolds to produce highly defined conjugates with small-molecule immunostimulators or antigens.

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“…Phospholipid headgroup can be zwitterionic, positively or negatively charged, while the hydrocarbon tail can vary in length and degree of unsaturation [3,4]. Due to its amphiphilicity, a liposome made of phospholipid can encapsulate polar drugs such as vitamin C in their aqueous compartment and nonpolar drugs such as beta-carotene in the lipid bilayers of the liposome membrane [5][6][7][8]. Te liposome-based drug delivery system works by delivering drugs directly to the active site (targeted delivery); thus, it is crucial to maintain the stability of the liposome membrane and the drug contained within it so that the drug may reach the target cell [9,10].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Phospholipid, Cholesterol, Beta-Carotene, and Vitamin C Molecules in Liposome-Based Drug Delivery Systems: An In Silico Study

Hudiyanti

Putri

Hikmahwati

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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This paper investigates the interaction within a liposome-based drug delivery system in silico. Results confirmed that phospholipids, cholesterol, beta-carotene, and vitamin C in the liposome structures interact noncovalently. The formation of noncovalent interactions indicates that the liposomal structures from phospholipid molecules will not result in chemical changes to the drug or any molecules encapsulated within. Noncovalent interactions formed include (i) moderate-strength hydrogen bonds with interaction energies ranging from −73.6434 kJ·mol−1 to −45.6734 kJ·mol−1 and bond lengths ranging from 1.731 Å to 1.827 Å and (ii) van der Waals interactions (induced dipole-induced dipole and induced dipole-dipole interactions) with interaction energies ranging from −4.4735 kJ·mol−1 to −1.5840 kJ·mol−1 and bond lengths ranging from 3.192 Å to 3.742 Å. The studies for several phospholipids with short hydrocarbon chains show that changes in chain length have almost no effect on interaction energy, bond length, and partial atomic charge.

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Drug delivery systems between metal, liposome, and polymer-based nanomedicine: A review

Cited by 27 publications

References 38 publications

Recent Advancements in Metallic Drug-Eluting Implants

Recent Advancements in Metallic Drug-Eluting Implants

Dendrimer for targeted drug delivery and Vaccine and Immunostimulatory: applications and methods

Interaction of Phospholipid, Cholesterol, Beta-Carotene, and Vitamin C Molecules in Liposome-Based Drug Delivery Systems: An In Silico Study

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