Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa, Sofia M.; Fangueiro, Raúl; Ferreira, Diana P.

doi:10.1002/mabi.202100512

Cited by 23 publications

(7 citation statements)

References 150 publications

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“…Photodynamic therapy involves the use of a photoactive molecule, light, and molecular oxygen present in tissues. When combined, these three compounds are capable of producing reactive oxygen species (ROS), which will induce target cell death [ 7 , 27 , 28 ]. Despite being a promising treatment, it has been used in a small number of patients, due to skin photosensitivity (the most common adverse effect) caused by systemically administered photosensitizers.…”

Section: Cancer Therapiesmentioning

confidence: 99%

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

et al. 2023

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Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area.

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Section: Cancer Therapiesmentioning

confidence: 99%

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

et al. 2023

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“…[88] [ 43,104] Viscosity Increase Nanofiber diameter increases; film pore size increases. [43,105,106] Conductivity Increase Nanofiber diameter decreases; film pore size decreases. [83] Surface tension Increase Nanofiber diameter decreases; film pore size decreases.…”

Section: Design Of Oriented Nanofibersmentioning

confidence: 99%

Rational Design of Advanced Triboelectric Materials for Energy Harvesting and Emerging Applications

Duan

Peng

et al. 2022

Small Methods

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The properties of materials play a significant role in triboelectric nanogenerators (TENGs). Advanced triboelectric materials for TENGs have attracted tremendous attention because of their superior advantages (e.g., high specific surface area, high porosity, and customizable macrostructure). These advanced materials can be extensively applied in numerous fields, including energy harvester, wearable electronics, filtration, and self‐powered sensors. Hence, designing triboelectric materials as advanced functional materials is important for the development of TENGs. Herein, the structural modification methods based on electrospinning to improve the triboelectric properties and the latest research progress in this kind of TENGs are systematically summarized. Preparation methods and design trends of nanofibers, microspheres, hierarchical structures, and doping nanomaterials are highlighted. The factors influencing the formation and properties of triboelectric materials are considered. Furthermore, the latest progress on the applications of TENGs is systematically elaborated. Finally, the challenges in the development of triboelectric materials are discussed, thereby guiding researchers in the large‐scale application of TENGs.

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“…Another advantage is the broad spectrum of therapy against gram-positive and gram-negative bacteria, fungi, viruses, and protozoa. However, the combination of aPDT with nanofibers is rather underrepresented in research, although it is gradually attracting more attention [ 21 ]. An in vivo study of polyurethane nanofibers with tetraphenylporphyrin reduced wound size and pain in chronic leg ulcers after visible light irradiation [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Photothermally Controlled Drug Release of Poly(d,l-lactide) Nanofibers Loaded with Indocyanine Green and Curcumin for Efficient Antimicrobial Photodynamic Therapy

et al. 2023

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Chronic wound infections with antibiotic-resistant bacteria have become a significant problem for modern healthcare systems since they are often associated with high costs and require profound topical wound management. Successful wound healing is achieved by reducing the bacterial load of the wound and providing an environment that enhances cell growth. In this context, nanofibers show remarkable success because their structure offers a promising drug delivery platform that can mimic the native extracellular matrix and accelerate cell proliferation. In our study, single-needle electrospinning, a versatile and cost-efficient technique, was used to shape polymers into an applicable and homogeneous fleece capable of a photothermally triggered drug release. It was combined with antimicrobial photodynamic therapy, a promising procedure against resistant bacteria. Therefore, poly(d,l-lactide) nanofibers loaded with curcumin and indocyanine green (ICG) were produced for local antimicrobial treatment. The mesh had a homogeneous structure, and the nanofibers showed a smooth surface. Recordings with a thermal camera showed that near-infrared light irradiation of ICG increased the temperature (>44 °C) in the surrounding medium. Release studies confirmed more than 29% enhanced curcumin release triggered by elevated temperature. The antimicrobial activity was tested against the gram-positive strain Staphylococcus saprophyticus subsp. bovis and the gram-negative strain Escherichia coli DH5 alpha. The nanofibers loaded with both photosensitizers and irradiated with both wavelengths reduced the bacterial viability (~4.4 log10, 99.996%) significantly more than the nanofibers loaded with only one photosensitizer (<1.7 log10, 97.828%) or irradiated with only one wavelength (<2.0 log10, 98.952%). In addition, our formulation efficiently eradicated persistent adhered bacteria by >4.3 log10 (99.995%), which was also confirmed visually. Finally, the produced nanofibers showed good biocompatibility, proven by the cellular viability of mouse fibroblasts (L929). The data demonstrate that we have developed a new economic nanofiber formulation, which offers a triggered drug release, excellent antimicrobial properties, and good biocompatibility.

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Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Cited by 23 publications

References 150 publications

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

Rational Design of Advanced Triboelectric Materials for Energy Harvesting and Emerging Applications

Photothermally Controlled Drug Release of Poly(d,l-lactide) Nanofibers Loaded with Indocyanine Green and Curcumin for Efficient Antimicrobial Photodynamic Therapy

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