Drug Delivery Systems in Regenerative Medicine: An Updated Review

Abstract

Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder their benefits. Moreover, advances in biotechnology resulted in the development of a new generation of molecules with a short half-life that necessitates frequent administration. In this context, controlled release systems are required to enhance treatment efficacy and improve patient compliance. Innovative drug delivery systems are promising tools that protect therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. The present review provides an overview of different approaches used for drug delivery.

Recent advances and future directions of 3D to 6D printing in brain cancer treatment and neural tissue engineering

“…By attaching targeting ligands, these particles can specifically target neural tissues and cells. In addition, they can also be loaded with various drugs such as proteins, small molecules, and nucleic acids [80]. In this regard, Lee et al [81] developed a 3D printed scaffold that mimics biological structures, containing core-shell nanoparticles created using electrospraying techniques to provide a slow and continuous release of neurogenic factors.…”

New role of bacteriophages in medical oncology

“…6 To date, many carriers from various construction materials have been developed for targeting, such as liposomes, polymeric nanoparticles, dendrimers, nanogels, and viruses (including phages). 7,8 With the major achievements of targeted therapy, efforts have in parallel been made which led to a better understanding of the tumor biology and identifying tumor-specific targets. With the information resulting from these predictive biomarkers, it can be predicted whether a particular treatment may be beneficial for one patient and not for another.…”

“…In targeted drug delivery systems, nanocarriers are combined with various targeting ligands such as antibodies, aptamers, and peptides to specifically interact with the intended receptor 6 . To date, many carriers from various construction materials have been developed for targeting, such as liposomes, polymeric nanoparticles, dendrimers, nanogels, and viruses (including phages) 7,8 . With the major achievements of targeted therapy, efforts have in parallel been made which led to a better understanding of the tumor biology and identifying tumor‐specific targets.…”

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

“…1 They are primarily aimed at improving therapeutic efficacy by providing the optimal or sustained release of bioactive agents; reducing administration frequency; ensuring continuous drug supply at therapeutic levels; achieving the targeted/specific delivery of drugs to the site of action; enhancing drug localisation; reducing off-target effects, minimising side effects; enhancing safety via the minimisation of systemic exposure; protecting drugs against enzymatic degradation, pH and other environmental conditions; improving drug stability and bioavailability; and increasing patient and treatment compliance and adherence. 2–6…”