Drug delivery systems using biotextiles

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

“…In the quest for efficient drug delivery systems, by means of systemic and topical routes, biotextile structures have been fashioned in a variety of formats, resembling interconnective tissues, the extracellular matrix and even organs. In fact, over the last fifty years, potential administration routes via biotextiles have gone from wounds, burns and dermatosis, the most common, to systemic diseases, implantable devices and nanoencapsulation [193]. Drug delivery systems based on biotextiles can now sustain local release, control deliverance, target cell/microorganism strains or biomolecules, and even boost smart release via local stimuli by means of topical, transdermal and implantable administration.…”

Controlled release of active agents from microcapsules embedded in textile structures

“…(Zhu and Yu, 2013). The fiber or fabrics could be first spun and woven, and then the active agents could be loaded by coating, impregnating, yarn-dying, ion-exchanging, spray immersing, soaking and rolling, etc.…”

“…The fiber or fabrics could be first spun and woven, and then the active agents could be loaded by coating, impregnating, yarn-dying, ion-exchanging, spray immersing, soaking and rolling, etc. Another method in preparing drug-loaded fibers is co-blending, which implies blending together the active agents and filament-forming materials to prepare the spinning liquids, which are later spun into fibers (Zhu and Yu, 2013). Core/shell fiber structures could be fabricated either by incorporating the drug in the shell, which is formed by coating a melt-spun fiber (Zilberman, 2007), or by adding an active agent to the core (Maleki et al, 2014).…”

Cellulose based aerogel microfibers for biomedical applications

“…By considering the difference in intrinsic functionality and physio-chemical properties of various materials, the selection of the right material or polymer plays a crucial role in designing and developing eluting drug textile. Natural, synthetic polymers, and inorganic compounds can be spun into fibers and form drug eluting textiles for versatile biomedical applications with varying properties, including macromoleculedrug interaction, drug loading efficiency, and release profiles [93].…”

“…For instance, in the case of inclusion complexes, known for creating slow-release systems, modifi ed cyclodextrins costs are high; also their fi nal fi xation on the textile surface is required since high dosage release of cyclodextrins can be toxic [77,93]. The fi ber spinning condition, fi nal morphology, and drug loading capacity are other factors that can limit the choice of impregnation method.…”