Drug Delivery to the Lymphatic System

Yang, Qiuhong; Forrest, Laird

doi:10.1002/9781118833322.ch21

Cited by 7 publications

(5 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particles larger than 100 nm stay at the site of administration until the phagosomal clearance. Lymphatic uptake and node accumulation is most significant between 10-80 nm [2]. The foreign body response is decreased by the application of spheres with a diameter of 1.5-2.5 mm compared to that of smaller diameter spheres [5].…”

Section: Microspheres and Microcapsulesmentioning

confidence: 95%

See 1 more Smart Citation

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

et al. 2019

View full text Add to dashboard Cite

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

show abstract

Section: Microspheres and Microcapsulesmentioning

confidence: 95%

“…An advantage of microcarriers over nanoparticles is that they do not traverse into the interstitium over the size of 100 nm transported by the lymph, and thus act locally [2]. Possibly toxic substances can be carried encapsulated and liquids can be handled as solids in the form of dried microparticles.…”

Section: Introductionmentioning

confidence: 99%

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The advantage of microcarriers over nanoparticles is that they do not cross the interstitium at a size of 100 nm and are transported by lymph and thus act locally [4]. Toxic substances can be solid in the form of micro-encapsulated and dried particles.…”

Section: Advantages Of Microparticlesmentioning

confidence: 99%

A review on recent advantages and evaluation of microparticles and their applications

Vinayak A. Katekar,

Prafful P. Kothari,

Aarti A. Nahar

et al. 2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

Microparticles are free spherical dust between 1 and 1000 microns made of synthetic, non-biodegradable, and non-biodegradable polymers. There are two types of microparticles: microcapsules and micro matrix. The main types of microparticles are magnetic microparticles, polymer microparticles, bio-adhesive microparticles, biodegradable polymer microparticles, synthetic polymer microparticles, floating microparticles, and radioactive microparticles. The advantage of microcarriers over nanoparticles is that they do not cross the 100 nm interstitium during lymphatic transport and therefore act locally. Toxic substances can be solidified in the form of micro-encapsulated and dried particles. Moreover, methods to characterize numerous physicochemical parameters like drug release, thermal properties, and particle size are introduced, along with new tests like in vitro leaching tests and floating tests.

show abstract

“…Microsphere particles of size above 100 nm remain at the administering site till phagocytic clearance. Microspheres uptake by the lymphatic system were notably between the size ranges from 10-80 nm [4]. The surface charge plays a significant role in the aggregation of particles.…”

Section: Introductionmentioning

confidence: 97%

Role of Microspheres in Novel Drug Delivery Systems: Preparation Methods and Applications

Kakkar

Wani

Gautam

et al. 2020

Int J Curr Pharm Sci

View full text Add to dashboard Cite

Microsphere based drug delivery system has gained substantial attention in the modern era. Microspheres are normally free-flowing powders that can be made with both natural and synthetic polymers. The sizes of the microspheres ranges from 1 to 1000 µm. Microspheres are matrix systems in which the drug is uniformly dispersed, dissolved or suspended. Microspheres contain solid or liquid drug dissolved or dispersed in a matrix system. The current review provides an inclusive outline of up to date and novel developments on formations of microspheres which have been reported to increase bioavailability, improves stability, enhances biological half-life and reduces the toxicity of the drug. Microsphere provides efficient delivery of various proteins and peptide molecules. There are different types of microspheres such as bio adhesive microsphere, magnetic microsphere, floating microsphere, and polymeric microspheres. Diverse kinds of methods are used in the formulation of microsphere e. g. Simple emulsion-based method, Double emulsion-based method, Interfacial deposition technique, Interfacial polymerization technique, Phase separation method, and Spray drying. Microspheres deliver the drug in a controlled manner through different routes like oral, topical, naso-pulmonary and gene therapy. The Polymeric based microspheres are model carriers for numerous controlled delivery applications owing to their capacity to encapsulate a diversity of drugs, bio-compatibility, high bio-availability and continuous drug release character. Therefore, by developing newer techniques, it can give more therapeutic effects and improves the safety of drugs. The formation of microspheres has been reported to increase bioavailability, improves stability, enhances biological half-life and reduces the toxicity of the drug.

show abstract

Drug Delivery to the Lymphatic System

Cited by 7 publications

References 153 publications

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

A review on recent advantages and evaluation of microparticles and their applications

Role of Microspheres in Novel Drug Delivery Systems: Preparation Methods and Applications

Contact Info

Product

Resources

About