Drug Delivery to Wounds, Burns, and Diabetes-Related Ulcers

Jain, Sandeep; Domb, Abraham J.; Kumar, Neeraj

doi:10.1007/978-1-4614-9434-8_26

Cited by 9 publications

(5 citation statements)

References 105 publications

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“…They added up to 3% w/v nanocellulose to the electrospinning solution to improve the mechanical properties of produced nanofibrous mat samples showed good antibacterial activity. Poly(vinyl alcohol) (PVA) is a synthetic biodegradable polymer with high absorption capacity, moisture maintenance, uniform adhesion to the injured skin, and high flexibility . Due to its relatively easily electrospinning ability and low price, it has been conducted in many nanofibrous mat production studies, therefore it was used as main substrate in this study.…”

Section: Introductionmentioning

confidence: 99%

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Zeighampour

Alihosseini

Morshed

et al. 2017

J of Applied Polymer Sci

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Propolis as a natural antibacterial agent was incorporated into the poly(vinyl alcohol) (PVA) in different forms of nanofiber, microfiber, and film. The successful fabrication of uniform nanofibers with 85-314 nm diameters and microfibers with 2.02 lm diameter was proved by scanning electron microscopy. Structural analysis by Fourier transform infrared spectroscopy and X-ray diffraction and swelling properties confirmed the formation PVA hydrogel and its H-bonding to the propolis. Evaluation and comparison of antimicrobial properties of produced samples against Staphylococcus aureus strains revealed that nanofiber mat with 19 mm inhibition zone has 11.76 and 26.67% higher efficiency against bacteria than microfiber mat and film with 17 and 15 mm inhibition zone, respectively. Nanofibrous mat showed sustained release during 96 h by maintaining full antibacterial activity up to 51 h which is of great importance in burn wounds. These results confirm the advanced performance of natural propolis in the form of nanofiber substrate as wound dressing.

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Section: Introductionmentioning

confidence: 99%

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Zeighampour

Alihosseini

Morshed

et al. 2017

J of Applied Polymer Sci

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“…The analysis was performed at a temperature of 25 °C with double distilled water as dispersion medium [19,20]. From the results all the formulations were found to be stable (Fig.…”

Section: Zeta Potentialmentioning

confidence: 99%

Formulation of Mefenamic Acid Loaded Ethosomal Gel by Hot and Cold Methods

Supraja¹,

Sailaja²

2017

Nano BioMed ENG

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The aim of the present study is the formulation of mefenamic acid ethosomal gel by hot and cold methods. To prepare the mefenamic acid transdermal gel, ethosomes was selected as colloidal carriers. Ethosomes were prepared by cold and hot methods. The obtained ethosomes were characterized with vesicular diameter, zeta potential, drug content, entrapment efficiency and in-vitro diffusion studies. The five formulations of ethosomes prepared by cold and hot methods were compared. Among the 10 formulations of ethosomes, E5 was considered as the best formulation because of its mean vesicular diameter of 854 nm, zeta potential of 20 mV, drug content of 96.3%, entrapment efficiency of 94.4%, sustained drug release for 12 hr, i.e. 94.4. Then the E5 formulations was incorporated into gel. A comparative study was made between the plain gel and the ethosomal gel. The Ethosomal gel was considered the best because of its highest drug content spreadability , pH (6.9) and the sustained drug release profile for 12 hr. By comparison, the cold method shows better results.

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“…From outdated medical cotton gauze to highly sophisticated moisture-balanced dressings, various types of dressings, including hydrogels [ 4 , 5 ], tissue adhesives [ 6 , 7 , 8 ], foams [ 9 , 10 ], alginates [ 11 , 12 ], and silicone-based materials [ 13 , 14 ], have been investigated to determine the optimum conditions in the wound healing processes [ 15 , 16 ]. Certain characteristics are needed for improved healing processes, which includes moisture-control, air permeability, exudate removal, antimicrobial, mechanical stability/elasticity, and biocompatibility/biodegradability [ 16 ]. In this study, Tencel, also known as lyocell, is used.…”

Section: Introductionmentioning

confidence: 99%

Plasma-Initiated Grafting of Bioactive Peptide onto Nano-CuO/Tencel Membrane

Chen

Shi

et al. 2022

Polymers

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A bioactive peptide has been successfully grafted onto nano-CuO impregnated Tencel membranes by a simple and rapid method involving a series of textile processes, and an atmospheric argon plasma treatment that requires no additional solvent or emulsifier. Surface morphology shows an apparent change from smooth, slightly roughened, and stripped with increasing plasma treatment time. The FT-IR characteristic peaks confirm the presence of the CuO nanoparticle and peptide on the extremely hydrophilic Tencel membranes that exhibit a zero-degree contact angle. Prepared nano-CuO/Tencel membranes with 90 sec plasma treatment time exhibit excellent antimicrobial activity against E. coli and S. aureus, and promote fibroblast cell viability with the assistance of a grafted bioactive peptide layer on the membrane surface.

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Drug Delivery to Wounds, Burns, and Diabetes-Related Ulcers

Cited by 9 publications

References 105 publications

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Formulation of Mefenamic Acid Loaded Ethosomal Gel by Hot and Cold Methods

Plasma-Initiated Grafting of Bioactive Peptide onto Nano-CuO/Tencel Membrane

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