Drug delivery using wireless MEMS

Sheybani, Roya; Schober, Susan; Meng, Ellis

doi:10.1533/9780857098610.2.489

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…This device was further evaluated in vivo in a clinical trial ( Farra et al, 2012 ). Devices containing two microchips and a total of 20 doses of lyophilized hPTH(1–34) were implanted in osteoporotic postmenopausal women for several months and wirelessly programmed to release daily doses ( Sheybani et al, 2013b ). Each microchip included 10 reservoirs (of 600 nL) containing 40 μg doses of hPTH(1–34).…”

Section: Implantable Mems Drug Delivery Devicesmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include longterm treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermalbased MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications.

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Section: Implantable Mems Drug Delivery Devicesmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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“…The volume delivered is controlled by the duration of pump activation. Heat generation from the wireless system is negligible in part due to chosen operation frequency (Sheybani, Schober et al 2013). High efficiency off the shelf components were chosen to minimize power dissipation (van Schuylenbergh and Puers 2009).…”

Section: Designmentioning

confidence: 99%

“…Several ongoing efforts are being carried out in research laboratories to develop remotely activated drug delivery microsystems. Detailed descriptions of these efforts are available in (Sheybani, Schober et al 2013, Cobo, Sheybani et al 2015). …”

Section: Introductionmentioning

confidence: 99%

A wireless implantable micropump for chronic drug infusion against cancer

Cobo

Sheybani

et al. 2016

Sensors and Actuators A: Physical

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We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling. Micropump performance was demonstrated using a model anti-cancer application in which daily doses of 30 μL were supplied for several weeks with less than 6% variation in flow rate within a single pump and less than 8% variation across different pumps. Pumping under different back pressure, viscosity, and temperature conditions were investigated; parameters were chosen so as to mimic in vivo conditions. In benchtop tests under simulated in vivo conditions, micropumps provided consistent and reliable performance over a period of 30 days with less than 4% flow rate variation. The demonstrated prototype has potential to provide a practical solution for remote chronic administration of drugs to ambulatory small animals for research as well as drug discovery and development applications.

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“…As a result, decreased power transfer due to coil distance leads to decreased flow rate. The decrease in power transfer with distance between the coils can be mitigated by increasing the power output of the transmitter [13]. …”

Section: Testing In Simulated Brain Tissue Materialsmentioning

confidence: 99%

“…Implantable pumps are advantageous for chronic treatment; eliminating transcutaneous wires and catheters permits improved patient mobility and allows drug administration outside of clinical settings [13]. Despite advances in miniaturization, batteries are still large in comparison to microelectromechanical systems (MEMS) pump actuators and can significantly increase device size.…”

Section: Introductionmentioning

confidence: 99%

On-demand wireless infusion rate control in an implantable micropump for patient-tailored treatment of chronic conditions

Sheybani

Meng

2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Wireless infusion rate control and programmability for an implantable, low power, electrochemical micropump is presented. Flow rate control was achieved through adjustment of the wiper position of a current potentiometer in the wireless receiver (0.6-3.2 mA output current with a resolution of 0.2 mA per step). An off-the-shelf Bluetooth module and Basic Stamp microcontroller kit was used to initiate amplitude-shift keying (ASK) modulation of the inductive power signal. Accurate flow control of two model regimens was achieved on benchtop. Wireless transmission (power transfer and control) was not affected by simulated tissue material placed between the transmitter and receiver.

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Drug delivery using wireless MEMS

Cited by 4 publications

References 25 publications

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

A wireless implantable micropump for chronic drug infusion against cancer

On-demand wireless infusion rate control in an implantable micropump for patient-tailored treatment of chronic conditions

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