Drug delivery with dissolving microneedles: skin puncture, its influencing factors and improvement strategies

Liu, Yong; Yanni, Wang; Ma, Fengsen

doi:10.1016/j.jddst.2022.103653

Cited by 26 publications

(12 citation statements)

References 120 publications

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“…The coated MPs have inferior drug loading capacity, while hollow MPs require a high-precision preparation technology, and moreover it may cause pore clogging during drug release. [140,141] The deposition of some soluble MPs in the skin can bring about side effects such as triggering an immune response in vivo. The lack of in-depth investigation into the pharmacokinetics of MPs' administration is key to limiting their practical application.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Multifunctional Microneedle Patches for Wound Healing and Health Monitoring

Pan

Liu

Wang

et al. 2022

Advanced NanoBiomed Research

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Benefiting from the advantages of minimal invasiveness, painlessness, and ease to use, microneedle patches (MPs) have been extensively studied in the biomedical field through a physical penetration enhancement pathway. This study systematically summarizes the preparation methods, function optimization, and diagnostic and therapeutic applications of MPs. First of all, the raw materials and methods commonly used in different preparation processes for MPs are highlighted. Then, the corresponding solutions to the problems facing MPs, such as poor tissue adhesion, weak mechanical strength, and low drug delivery utilization in their development and application, are emphasized, which serve as approaches to improve the performance of MPs. Subsequently, the latest applications of MPs for wound healing and health monitoring in recent years are summarized in‐depth, revealing the unique merits of MPs in diagnosis and treatment. Finally, the key points for the urgent improvement of MPs in clinical translation and commercial application are deliberated, in order to inspire the future direction of multifunctional and intelligent MPs.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Multifunctional Microneedle Patches for Wound Healing and Health Monitoring

Pan

Liu

Wang

et al. 2022

Advanced NanoBiomed Research

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“…However, it is necessary to take in consideration that longer needles may lead to molecules release into the lower end of the dermis and their absorption by skin microcirculation [148,149]. It is also important to bear in mind that nerve endings are distributed in the deep dermis of the skin, so a microneedle with a longer length is more likely to activate pain receptors, or puncture capillaries causing bleeding, which may reduce patient acceptability [150]. Gill et al studied the correlation between microneedle length and pain.…”

Section: Lengthmentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

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“…The mechanical strength of pMNs is challenged by the large number of micropores inside the needle body, which may result in a lack of rigidity of pMNs and consequently the inability to penetrate the skin. 16 However, MNs with sufficient mechanical strength are a necessary prerequisite for their ability to puncture the skin and function. 7 In order to enhance the mechanical properties of pMNs, some researchers 8 improved it by adjusting the porosity and pore size.…”

Section: Introductionmentioning

confidence: 99%

Coated Porous Microneedles for Effective Intradermal Immunization with Split Influenza Vaccine

Zhang,

Xiu,

et al. 2023

ACS Biomater. Sci. Eng.

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In order to alleviate the pain associated with subcutaneous injections, microneedles (MNs) are gaining increasing attention as a novel transdermal drug delivery modality. Among them, porous microneedles (pMNs) are particularly suitable for the delivery of drugs and vaccines whose activity is sensitive to the microneedle preparation process. They can carry drugs actively to achieve an effective load and deliver drugs into the skin. In this study, the biocompatible cellulose acetate (CA) microporous MNs with a large pore size of 1.13 μm ± 0.45 and a high porosity of 74.8% ± 2.8% were prepared by using a safe nonsolvent-induced phase separation (NIPS) method. The MN patches prepared after adsorption of appropriate concentrations of split influenza vaccine fully met the dose loading requirements. A biocompatible carboxymethyl cellulose (CMC) solution was used in the pMN coating to strengthen their mechanical properties, with an average maximum stress of 32.89 N, and to act as a medium for the dispersion of an adjuvant in the coating layer. The influenza vaccine adsorbed in the micropore and the adjuvant dispersed in the coating were released intradermally to exert synergistic effects with different release patterns and rates. The coated pMNs induced an efficient immune response in Wistar rats with a hemagglutination inhibition (HI) titer of ≥1024, which was comparable to that of intramuscular injection. The research is organized around the goal of engineering exploration of innovative technologies, suggesting that pMNs have a tantalizing prospect for future applications. It opens up the possibility of eventually obtaining a simple, easy-to-use, and efficient application technology for the prevention of global epidemics like influenza.

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Drug delivery with dissolving microneedles: skin puncture, its influencing factors and improvement strategies

Cited by 26 publications

References 120 publications

Recent Advances in Multifunctional Microneedle Patches for Wound Healing and Health Monitoring

Recent Advances in Multifunctional Microneedle Patches for Wound Healing and Health Monitoring

Microneedles Patch: Design, Fabrication and Applications

Coated Porous Microneedles for Effective Intradermal Immunization with Split Influenza Vaccine

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