Drug Discovery from Natural Sources

Newman, David J.

doi:10.1007/s40495-023-00313-3

Cited by 9 publications

(4 citation statements)

References 96 publications

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“…Numerous case studies illustrate the successful application of these methods. The semi-synthesis of bioactive compounds such as paclitaxel, bioactive terpenoids, steroids, and polyketides from uncultivated bacterial symbionts demonstrates the potential of these approaches (Wang & Hui, 2021;Newman, 2023). Biotechnological advancements, including plant tissue culture and microbial fermentation, further highlight the feasibility of producing these compounds at scale (Ribaudo, 2023).…”

Section: Addressing Amr Through Medicinal Plant Compoundsmentioning

confidence: 99%

“…Biotechnological advancements, including plant tissue culture and microbial fermentation, further highlight the feasibility of producing these compounds at scale (Ribaudo, 2023). Genetic engineering has also been utilized to produce complex natural products like artemisinin through yeast, addressing challenges associated with traditional extraction methods from Artemisia annua (Newman, 2023).…”

Section: Addressing Amr Through Medicinal Plant Compoundsmentioning

confidence: 99%

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Transformative Natural Product-Drug Combinations Pioneering Techniques for Enhanced Efficacy Against Drug-Resistant Pathogens for drug discovery and development.

Gideon

2024

Preprint

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This study aims to develop, modify, or optimize potent active compounds by utilizing combinatorial synthetic methods involving phytoconstituents from plant extracts to enhance efficacy and reduce resistance potential. We employed ATR-FTIR, GC-MS, and antibacterial results from related literature to validate these strategies. The methodology involved careful harvesting, pre-treatment, and extraction processes to ensure the quality and efficacy of plant extracts. We used various extraction methods and solvents to isolate specific phytoconstituents, followed by further purification using chromatography. The study proposes three strategies: (1) reacting single or multiple plant extracts with reagents like acids or catalysts, (2) combining plant extracts with ineffective drugs to induce structural changes that enhance antibacterial efficacy, and (3) combining plant extracts with drugs not originally intended for the target disease to explore new structural functionalities. Notable results included the synergistic effects observed in combining Psidium guajava and Calotropis procera extracts with antibiotics, significantly increasing zones of inhibition against resistant bacteria. GC-MS analysis identified numerous bioactive compounds, some with known anticancer properties, suggesting potential applications beyond antibacterial effects. Our findings demonstrate that these innovative combinatorial approaches can yield new compounds with enhanced antimicrobial properties, highlighting the potential of plant extracts in drug discovery and development. This study underscores the promise of harnessing natural products to combat multi-drug resistance, paving the way for advanced research and development in pharmaceutical applications.

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Section: Addressing Amr Through Medicinal Plant Compoundsmentioning

confidence: 99%

Section: Addressing Amr Through Medicinal Plant Compoundsmentioning

confidence: 99%

Transformative Natural Product-Drug Combinations Pioneering Techniques for Enhanced Efficacy Against Drug-Resistant Pathogens for drug discovery and development.

Gideon

2024

Preprint

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“…[1][2][3] Over the years, different organisms have been considered as starting points of the Nature-Aided Drug Discovery (NADD) process, e.g., plants, lichens, animals, and microorganisms, either terrestrial or marine. 4 The successes achieved pursuing this approach are many and well-known. 5 The wide chemical diversity is the strength of natural products (NPs), which allows molecules to be obtained with various mechanisms of action and, therefore, suitable for various fields of application.…”

Section: Introductionmentioning

confidence: 99%

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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“…the distribution of AMPs according to their deriving life kingdom is graphically represented. These peptides can be naturally produced by organisms as a mechanism of defense against pathogens and other threats in biological endogenous processes, but like other bioactive peptides, can also be obtained through fermentation, digestion, extraction, and hydrolysis[107][108][109]. Peptides with biological activity can also be synthesized based on a predicted biological function of the sequence and its characteristics, taking the structure of natural peptides as a model but not directly derived from them[110][111][112].…”

mentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Drug Discovery from Natural Sources

Cited by 9 publications

References 96 publications

Transformative Natural Product-Drug Combinations Pioneering Techniques for Enhanced Efficacy Against Drug-Resistant Pathogens for drug discovery and development.

Transformative Natural Product-Drug Combinations Pioneering Techniques for Enhanced Efficacy Against Drug-Resistant Pathogens for drug discovery and development.

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Bioactive peptides as alternative treatment for Helicobacter pylori infection

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