Drug discovery: Past, present and future

Genomics, Bioregulators, Cell Receptors and Potential Biological Weapons

“…Furthermore, the revolution in information technology has provided new tools for carrying out such work: 34 The computer technology evolving at a rapid pace has made available a number of software packages that allow a visual on-screen study of the receptor-ligand binding in order to arrive at structures with optimum levels of desired activity.…”

“…As knowledge of chemistry developed, it proved possible, for example, for Serturner to purify morphine from crude opium in 1806, and by the end of the century, Paul Ehrlich was able to demonstrate that pathogenic infections could be treated by administering speci c chemicals. 34 The standard approach developed by the 1930s was for a "lead compound" to be subjected to systematic modi cation so that the most active -and least toxic -of its derivatives could be discovered. Knowledge of the body's functional systems remained very limited though and in spite of much effort going into "rational design" of drugs, analysis shows that there are few examples of rational design of "wonder drugs" in the twentieth century.…”

Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification

“…The computational approaches are widely known for their effectiveness in facilitating drug design and discovery (Kaul 1998 ). Quantitative structure–activity relationships (QSAR) is an in silico method for correlating structures of the compounds with their biological activities (Nantasenamat et al 2009 , 2010 ).…”

Pesquisa e desenvolvimento de fármacos no Brasil: estratégias de fomento

“…Embora a medicina alopática praticada na atualidade tenha sua origem na cultura grega, o uso de plantas na medicina era muito difundido no Egito, Índia e China há mais de 8000 anos (BARROS, 1995;DIXON, 1981;KAUL, 1998).…”

“…O terceiro período, embora ainda não tenha alcançado todos os resultados esperados, teve início no final dos anos 70, com o uso das ferramentas de engenharia genética na produção e descoberta de novos fármacos (MALERBA; ORSENIGO, 2001 (DREWS, 2000;GIBBS, 2000;KAUL, 1998;REICH, 2000;ROSAMOND;ALLSOP, 2000;SANDER, 2000;SCHREIBER, 2000).…”