2016
DOI: 10.1037/bar0000032
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Drug discrimination and the analysis of private events.

Abstract: A defining feature of radical behaviorism is the explicit inclusion of private events as material phenomena within a science of behavior. Surprisingly, however, despite much theorizing, there is a notable paucity within behavior analysis of controlled experimentation and analysis of private events, especially in nonhuman animals. One technique that is amenable to the study of private events is drug discrimination. For over 40 years, drug discrimination procedures have been an incredibly effective tool providin… Show more

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Cited by 5 publications
(4 citation statements)
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“…The fundamental principle of the drug-discrimination paradigm is that the acquisition of a drug stimulus as an internal cue depends on the ability of the animal to differentiate the psychoactive state induced by the drug from their baseline subjective state (Kangas and Maguire, 2016;Preston and Bigelow, 1991). One interpretation of our main finding that MIA (but not control) animals had difficulty differentiating the internal states produced by ketamine and saline is that the baseline internal state of MIA rats resembles the state induced by intermediate doses of ketamine.…”
Section: Discussionmentioning
confidence: 99%
“…The fundamental principle of the drug-discrimination paradigm is that the acquisition of a drug stimulus as an internal cue depends on the ability of the animal to differentiate the psychoactive state induced by the drug from their baseline subjective state (Kangas and Maguire, 2016;Preston and Bigelow, 1991). One interpretation of our main finding that MIA (but not control) animals had difficulty differentiating the internal states produced by ketamine and saline is that the baseline internal state of MIA rats resembles the state induced by intermediate doses of ketamine.…”
Section: Discussionmentioning
confidence: 99%
“…We suggest that our results strongly indicate that the subjective internal state experienced by MIA rats is similar to that experienced in human psychosis. These results provide a methodological basis for exploring the impact of MIA on subjective internal states and related behavioral phenomena such as human psychosis, and could provide means for better understanding neurobiological or molecular mechanisms of this phenomenon as it relates to schizophrenia (Kangas & Maguire, 2016).…”
Section: Toward Modeling Psychosismentioning
confidence: 93%
“…Indeed, notwithstanding copious conceptual and theoretical treatises, there have been relatively few controlled laboratory studies examining private events. One exception that has proven fruitful is the use of behavioral techniques to bring operant behavior under the control of interoceptive events produced by drug treatment, with drug discrimination being one of the most prominent examples (reviewed in Kangas & Maguire, 2016). Other studies have used drug treatment in human subjects to produce equivalence relations between interoceptive (drug) and exteroceptive (visual) stimuli (DeGrandpre, Bickel, & Higgins, 1992) and in pigeons to model interpersonal communication of private events produced by distinctive interoceptive effects associated with different drug classes (Lubinski & Thompson, 1987).…”
Section: Additional Benefits Of Developing Translational Models Of Painmentioning
confidence: 99%