Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA

Abstract

To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.

An Electrochemical Approach to Follow and Evaluate the Kinetic Catalysis of Ricin on hsDNA

“…Herring sperm DNA (hsDNA) is considered as a target molecule in studies of antitumor and anticancer drugs, binding agents, the modulation of DNA structure and function [ 12 ], and physicochemical behavior in solution [ 13 , 14 ]. As reported elsewhere, hsDNA can be considered as a good substrate for ricin [ 15 , 16 ].…”