Drug effects on electrical activities of the canine tracheal ciliated cells.

Yanaura, Saiζo; Imamura, Naoto; Hosokawa, Tomokazu; Takeda, Hiroshi; Misawa, Miwa

doi:10.1248/bpb1978.2.266

Cited by 6 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This oscillating component was considered to function as a 'pace-maker' in order to control ciliary activity. In a study on canine trachea, Yanaura et al [8] concluded that the electrical activity is closely re lated to the ciliary activity in the beating cell. Conse quently, a drug [6] able to modify so dramatically transepithelial potential difference (-24% in healthy subjects and -90% in cystic fibrosis patients) could have an effect on ciliary activity as well.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Amiloride on Human Bronchial Ciliary Activity in vitro

Benedetto

Lopez-Vidriero²,

Carratù³

et al. 1990

Respiration

View full text Add to dashboard Cite

Amiloride (AM) reduces mucociliary transport in the frog palate in vitro preparation, whereas in vivo inhalation of AM enhances mucociliary and cough clearance in cystic fibrosis patients. AM influences the bioelectric properties of the respiratory mucosa, and since electrical activity and ciliary activity are strictly related in the beating cell, an effect on ciliary function cannot be excluded. We have, therefore, investigated the effect of AM (10^-7 to 10^-3M) in vitro on the ciliary activity often samples of healthy human bronchial epithelium at 37 °C. The baseline ciliary beat frequency was 13.7 ± (SD)1.0 Hz. At concentrations of AM of 10^-4 and 10^-3M, small statistically significant (p < 0.01) increases in ciliary beat frequency were recorded only after 1 min of exposure to the drug, with changes of +8.2 and +7.6%, respectively. We conclude that (1) AM affects the ciliary activity of the beating cell, but (2) because of the weakness and short duration of the effect, it is unlikely that AM plays a major role on mucociliary transport

show abstract

Section: Discussionmentioning

confidence: 99%

“…AM influences the bio electric properties of the respiratory mucosa [6], and there is a close relationship between electrical activity and ciliary activity in the beating cell [7,8]. We, there fore, investigated the effect of AM on the ciliary activ ity of human bronchial epithelium in vitro.…”

Section: Introductionmentioning

confidence: 99%