Drug Effects on Postlabyrinthectomy Nystagmus

McCabe, Brian F.; Sekitani, Toru; Ryu, Jae-Yong

doi:10.1001/archotol.1973.00780020322006

Cited by 23 publications

(3 citation statements)

References 6 publications

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“…Sekitani et al (24) and McCabe et al (25) reported that diazepam and other sedative/hypnotic drugs of the benzodiazepine class affected the central vestibular system and depressed UL-induced SN in cats. Martin et al (26) recently demonstrated that these caused reappearance of SN toward the labyrinthineintact side (7).…”

Section: Role Of the Nmda Receptor In Vestibular Compensationmentioning

confidence: 99%

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Kitahara¹,

Takeda²,

Kiyama³

et al. 1998

Acta Oto-Laryngologica

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T. Molecular mechanisms of 6estibular compensation in the central 6estibular system-re6iew. Acta Otolaryngol (Stockh) 1998; Suppl 539: 19 -27. Vestibular compensation consists of two stages: the inhibition of the contralesional medial vestibular nucleus (contraMVe) activities at the acute stage after unilateral labyrinthectomy (UL) and the recovery and maintenance of the ipsilesional MVe (ipsi-MVe) spontaneous activities at the chronic stage after UL. In this paper, we reviewed molecular mechanisms of vestibular compensation in the central vestibular system using several morphological and pharmacological approaches in rats. Based on our examinations, we propose the following hypotheses: i) at the acute stage after UL, the activated neurons in the ipsi-MVe project their axons into the flocculus to inhibit the contra-MVe neurons via the NMDA receptor, nitric oxide (NO) and/or GABA-mediated signalling, resulting in the restoration of balance between intervestibular nuclear activities. ii) At the chronic stage after UL, the flocculus depresses the inhibitory effects on the ipsi-MVe neurons via protein phosphatase 2A (PP2A) beta, protein kinase C (PKC) and glutamate receptor (GluR) delta-2, to help the recovery and maintenance of ipsi-MVe activities.

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Section: Role Of the Nmda Receptor In Vestibular Compensationmentioning

confidence: 99%

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Kitahara¹,

Takeda²,

Kiyama³

et al. 1998

Acta Oto-Laryngologica

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“…Furthermore, animal studies suggest that diazepam can reduce SN frequency (McCabe et al, 1973;Bernstein et al, 1974; but see Peppard, 1986;Martin et al, 1996 for conflicting data). Magnusson et al (2000Magnusson et al ( , 2002 have reported complex effects of systemic injections of the partial GABA A receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride (THIP) and i.c.v.-injected muscimol, on SN compensation.…”

mentioning

confidence: 99%

“…Neither of these methods provides information on the site of drug action. Furthermore, some of the behavioral studies have used THIP and diazepam, and neither are full GABA A receptor agonists (McCabe et al, 1973;Bernstein et al, 1974;Peppard, 1986;Martin et al, 1996;Magnusson et al, 2002). Neither has there been any systematic investigation of the role of GABA A receptors in postural compensation.…”

mentioning

confidence: 99%

Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

Gliddon

Darlington²,

Smith³

2005

J Pharmacol Exp Ther

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The aim of this study was to determine the effects of chronic infusion of a GABA A receptor agonist/antagonist into the ipsilateral or contralateral vestibular nuclear complex (VNC) on vestibular compensation, the process of behavioral recovery that occurs after unilateral vestibular deafferentation (UVD). This was achieved by a mini-osmotic pump that infused, over 30 h, muscimol or gabazine into the ipsilateral or contralateral VNC. Spontaneous nystagmus (SN), yaw head tilt (YHT), and roll head tilt (RHT) were measured. Infusion of muscimol or gabazine into either the ipsilateral or the contralateral VNC had little effect on SN compensation. In contrast, infusion of muscimol (250, 500, and 750 ng) into the contralateral VNC and gabazine (31.25, 62.5, and 125 ng) into the ipsilateral VNC significantly affected YHT and RHT (p Ͻ 0.05), but not their rate of compensation (p Ͼ 0.05). Interestingly, the effects of muscimol and gabazine on YHT and RHT were consistent throughout the first 30 h post-UVD. Infusion of muscimol (62.5, 125, and 250 ng) into the ipsilateral VNC and gabazine (125, 375, and 750 ng) into the contralateral VNC had little effect on YHT and RHT or their rate of compensation. These results suggest that the ipsilateral gabazine and contralateral muscimol infusions are modifying the expression of the symptoms without altering the mechanism of compensation. Furthermore, the neurochemical mechanism responsible for vestibular compensation can cope with the both the GABA A receptor-mediated and the UVD-induced decrease in resting activity.

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Vestibulo-ocular Reflexes in Rabbits

Barmack¹,

Pettorossi

1980

Arch Neurol

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Drug Effects on Postlabyrinthectomy Nystagmus

Cited by 23 publications

References 6 publications

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

Vestibulo-ocular Reflexes in Rabbits

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Drug Effects on Postlabyrinthectomy Nystagmus

Cited by 23 publications

References 6 publications

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Molecular Mechanisms of Vestibular Compensation in the Central Vestibular System - Review

Effects of Chronic Infusion of a GABAA Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

Vestibulo-ocular Reflexes in Rabbits

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Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig