Drug-Eluting Balloon for Treatment of Superficial Femoral Artery In-Stent Restenosis

Stabile, Eugenio; Virga, Vittorio; Salemme, Luigi; Cioppa, Angelo; Ambrosini, Vittorio; Sorropago, Giovanni; Tesorio, Tullio; Cota, Linda; Popusoi, Grigore; Pucciarelli, Armando; Biamino, Giancarlo; Rubino, Paolo

doi:10.1016/j.jacc.2012.07.033

Cited by 130 publications

(83 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As much as the correlation between calcium and DEB performance appears clear, overall 12-month LLL of 0.61 ± 0.15 mm is similar to the results reported in other studies and obviously better than the LLL reported using conventional angioplasty [13][14][15][16][17][18][19][20].…”

Section: Discussionsupporting

confidence: 84%

“…In recent prospective studies, DEB have shown a primary patency at 1 year comprised between 83.7 [16] and 92.1 % [17]. Other studies comparing DEB versus PTA found a primary patency of DEB significantly higher compared with PTA: Tepe et al [14] reported a 6-month [15], who found in patients with femoropopliteal and infragenicular vascular disease a primary patency rate at 12 months of 76 % for DEB versus 39.6 % for the PTA arm (p = 0.04).…”

Section: Discussionmentioning

confidence: 99%

“…Several trials and studies have reported their efficacy to reduce restenosis rate for the treatment of femoro-popliteal and below-the-knee lesions [13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Calcium Burden Assessment and Impact on Drug-Eluting Balloons in Peripheral Arterial Disease

Fanelli

Cannavale

Gazzetti

et al. 2014

Cardiovasc Intervent Radiol

318

235

View full text Add to dashboard Cite

Purpose This study was designed to assess the effect of calcium on the efficacy of DEB during revascularization of steno-obstructive SFA lesions. Methods Sixty patients with de novo lesions of the superficial femoral artery underwent endovascular treatment with drug eluting balloons (DEB). DEB was selected according to vessel reference diameter (1:1). In case of residual stenosis [ 50 % or flow-limiting dissection, postdilatation with conventional balloon or provisional stenting was done. Patients were classified into eight groups according to circumferential distribution of calcium on CT-angiography axial images (from 0°to 360°) and to its length (length \ or [ 3 cm) evaluated with digitalsubtraction-angiography. Ankle-brachial index (ABI), late lumen loss (LLL), target lesion revascularization (TLR), primary (PP) and secondary (SP) patency, major adverse events (MAE), and Rutherford shift were evaluated at 1-year follow-up and correlated with the amount of calcium.Results Revascularization was successful in all cases. Flow-limiting dissection occurred in five cases (8.3 %) with a higher circumferential degree of calcium and solved in three cases with postdilatation and in the other two with provisional stenting. DEB effect was lower in patients with higher degree of calcium ([270°vs. \90°): ABI 0.71 ± 0.07 versus 0.92 ± 0.07; LLL 0.75 ± 0.21 versus 0.45 ± 0.1; PP 50 versus 100 %; SP 50 versus 100 %; TLR 25 versus 0 %; MAE 25 versus 0 %. Conclusions Calcium represents a barrier to optimal drug absorption. Circumferential distribution seems to be the most influencing factor with the worst effect noticed in 360°calcium presence.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Calcium Burden Assessment and Impact on Drug-Eluting Balloons in Peripheral Arterial Disease

Fanelli

Cannavale

Gazzetti

et al. 2014

Cardiovasc Intervent Radiol

318

235

View full text Add to dashboard Cite

show abstract

“…11 However, for superficial femoral artery (SFA) ISR, currently available data are poor. In a small, prospective registry of DCBA for SFA ISR, 12,13 recurrent restenosis rates were 7.9% (4 of 39) and 29.7% (11 of 37) at 12 and 24 months, respectively. For diabetic patients, Liistro et al 14 reported significantly lower recurrent ISR rates at 12 months after DCBA compared with a historical POBA group (19.5% [8 of 41] …”

Section: Editorial See P 2198 Clinical Perspective On P 2236mentioning

confidence: 99%

Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis

et al. 2015

View full text Add to dashboard Cite

Background-Drug-coated balloon angioplasty (DCBA) was shown to be superior to standard balloon angioplasty (POBA) in terms of restenosis prevention for de novo superficial femoral artery disease. For in-stent restenosis, the benefit of DCBA over POBA remains uncertain. Methods and Results-One hundred nineteen patients with superficial femoral artery in-stent restenosis and chronic limb ischemia were recruited over 34 months at 5 German clinical sites and prospectively randomized to either DCBA (n=62) or POBA (n=57

show abstract

“…The clinical study indicates that it is a secure and effective surgical method to treat restenosis in SFA. However, this led to cardiac failure in some cases and hence more studies may be necessary on patients with comorbidities [21]. In succession to angioplasty, stent implantation and bypass graft, other examination techniques can be used to follow up the patients' health condition.…”

Section: Introductionmentioning

confidence: 99%

Flow Dynamics and Wall Shear Stresses in a Bifurcated Femoral Artery

Gogineni¹,

Ts²

2017

J Biomed Eng Med Devic

View full text Add to dashboard Cite

The present paper presents peak wall shear stresses and velocities in a bifurcated femoral artery. This artery is modeled along with blockage downstream of bifurcation, blockage at bifurcation, blockage downstream of stented femoral artery. The femoral artery is subjected to peripheral artery disease. A two-dimensional computational fluid dynamic analysis is conducted in all the models, assuming steady blood flow and seventy percent plaque. However, the blood viscosity and blood pressure vary in the femoral artery models as they are subjected to other medical conditions. Femoral artery bifurcates into profunda femoris and the bifurcation angles are assumed to vary at 30, 45 and 60 degrees. The blocked bifurcated artery is replaced with a wall stent and in many cases, a blockage develops downstream of the bifurcated stented artery as a consequence of stent implantation. The wall shear stresses and velocities results from the bifurcated and blocked femoral arterial models are compared to a normal artery characteristic. Further, a comparative study has been conducted along the blocked bifurcated artery with and without the stent.

show abstract

Drug-Eluting Balloon for Treatment of Superficial Femoral Artery In-Stent Restenosis

Abstract: The data suggest that adjunctive use of DEB for the treatment of SFA-ISR represents a potentially safe and effective therapeutic strategy. These data should be considered hypothesis-generating to design a randomized trial.

Cited by 130 publications

References 14 publications

Calcium Burden Assessment and Impact on Drug-Eluting Balloons in Peripheral Arterial Disease

Calcium Burden Assessment and Impact on Drug-Eluting Balloons in Peripheral Arterial Disease

Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis

Flow Dynamics and Wall Shear Stresses in a Bifurcated Femoral Artery

Contact Info

Product

Resources

About