Drug Eluting Bioresorbable Cellulose Acetate/PEO/HPMC Composite With Propolis Extracts for Suturing Application

Ramadoss, P.; Arivuoli, D.; Basha, Sabiha Hayath

doi:10.52687/2348-8956/822

Cited by 1 publication

(1 citation statement)

References 24 publications

(37 reference statements)

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“…The importance of propolis in wound healing may be attributed to its bacterial and biofilm formation inhibition, which was demonstrated against staphylococci, streptococci, and some antibiotic-resistant tuberculosis strains [ 21 ]. Previous studies have demonstrated the beneficial role of propolis in nanostructured lipid carriers for stopping breast cancer evolution [ 22 ], in cellulose acetate/polyethylene oxide/hydroxypropyl methyl cellulose composite to obtain a drug-releasing resorbable suture material [ 23 ], and in dressing for wound healing based on bacterial cellulose (BC) incorporating propolis and Cinnamomum cassia essential oil, which, as expected, inhibited the growth of Gram-positive bacteria, while also affecting the growth of Gram-negative bacteria [ 16 ]. Propolis was also used to induce antimicrobial activity in nanocellulose-containing polymer composites [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Nanocellulose with Antibacterial Activity for Wound Healing Dressing

Oprică,

Panaitescu,

Lixandru

et al. 2023

Pharmaceutics

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The medical sector is one of the biggest consumers of single-use materials, and while the insurance of sterile media is non-negotiable, the environmental aspect is a chronic problem. Nanocellulose (NC) is one of the safest and most promising materials that can be used in medical applications due to its valuable properties like biocompatibility and biodegradability, along with its good mechanical properties and high water uptake capacity. However, NC has no bactericidal activity, which is a critical need for the effective prevention of infections in chronic diabetic wound dressing applications. Therefore, in this work, a natural product, propolis extract (PE), was used as an antibacterial agent, in different amounts, together with NC to obtain sponge-like structures (NC/PE). The scanning electron microscope (SEM) images showed well-impregnated cellulose fibers and a more compact structure with the addition of PE. According to the thermogravimetric analysis (TGA), the samples containing PE underwent thermal degradation before the unmodified NC due to the presence of volatile compounds in the extract. However, the peak degradation temperature in the first derivative thermogravimetric curves was higher for all the sponges containing PE when compared to the unmodified NC. The antibacterial efficacy of the samples was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, as well as on two clinically resistant isolates. The samples completely inhibited the development of Staphylococcus aureus, and Pseudomonas aeruginosa was partially inhibited, while Escherichia coli was resistant to the PE action. Considering the physical and biological properties along with the environmental and economic benefits, the development of an NC/PE wound dressing seems promising.

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