Drug eluting stent-induced Kounis syndrome

Kounis Syndrome secondary to cefuroxime axetil use in an asthmatic patient

“…Main pathophysiological mechanism is vasospasm of epicardial coronary arteries due to increased inflammatory mediators that are released during a hypersensitivity reaction [1]. The trigger may be drugs [2][3][4][5][6][7], chemicals [9], foreign bodies [10][11][12][13][14], environmental exposures [8,[24][25][26][27][28] or some other conditions that give rise to inflammatory mediator release [15]. Anaphylactic or anaphylactoid reactions can make clinical situation even more serious.…”

Amoxicillin-induced Kounis syndrome manifesting as late stent thrombosis

“…Although association previous PCI and KS has been already reported [8,9], this is the first description of the syndrome, induced by an urticaria, due to a very late stent thrombosis. The culprit lesion was the thrombosis of BMS previous implanted.…”

Kounis syndrome in a patient with ovarian cancer and allergy to iodinated contrast media: Report of a case

“…This topic is an important one since patients affected by ischemic heart disease receiving stent implantation can be prone to hypersensitivity reactions from five potential antigens, namely nickel strut, polymer coating, eluted drug, clopidogrel and aspirin [10]. Some hypersensitivity cases have indeed been associated with implantation of drug eluting coronary stents [11][12][13] and between them a case of intra-stent thrombosis in a subject with allergy to larvae of fly carvaria [14].…”