Drug-eluting wound dressings having sustained release of antimicrobial compounds

Gámez-Herrera, Enrique; García-Salinas, Sara; Salido, Sofı́a; Sancho‐Albero, María; Andreu, Vanesa; Pérez, Marta; Luján, Lluís; Irusta, Silvia; Arruebo, Manuel; Mendoza, Gracia

doi:10.1016/j.ejpb.2020.05.025

Cited by 30 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NFs are non-toxic to human dermal fibroblasts (HDF) cells [ 102 ]. Furthermore, it has also been reported that HA-ZnO nanocomposite enhanced the cytocompatibility of essential oils [ 103 , 104 ]. After 24 h, all antibacterial NFs formulations showed excellent antibacterial activity against S. aureus .…”

Section: Ha-mnps and Wound Healing Applicationsmentioning

confidence: 99%

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Sudhakar

Rao

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Hyaluronic acid (HA) based nanocomposites are considered excellent for improving wound healing. HA is biocompatible, biodegradable, non-toxic, biologically active, has hemostatic ability, and resists bacterial adhesion. HA-based nanocomposites promote wound healing in four different sequential phases hemostasis, inflammation, proliferation, and maturation. The unique biological characteristics of HA enable it to serve as a drug, an antibacterial agent, and a growth factor, which combine to accelerate the healing process. In this review, we focus on the use of HA-based nanocomposites for wound healing applications and we describe the importance of HA for the wound healing process in each sequential phase, such as hemostasis, inflammation, proliferation, and maturation. Metal nanoparticles (MNPs) or metal oxide nanoparticles (MO-NPs) loaded with HA nanocomposite are used for wound healing applications. Insights into important antibacterial mechanisms are described in HA nanocomposites. Furthermore, we explain antibiotics loaded with HA nanocomposite and its combination with the MNPs/MO-NPs used for wound healing applications. In addition, HA derivatives are discussed and used in combination with the other polymers of the composite for the wound healing process, as is the role of the polymer in wound healing applications. Finally, HA-based nanocomposites used for clinical trials in animal models are presented for wound healing applications.

show abstract

Section: Ha-mnps and Wound Healing Applicationsmentioning

confidence: 99%

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Sudhakar

Rao

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Bacterial contamination of a wound might occur at any time during the wound healing process; therefore, prolonged antimicrobial agent release from the wound dressing is beneficial [ 31 ]. We believe that prolonged release of tannic acid may be beneficial to the antibacterial properties of a material.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid

Michalska‐Sionkowska

Warżyńska

Kaczmarek-Szczepańska

et al. 2021

Polymers

View full text Add to dashboard Cite

Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials’ extracts improved the HaCaT cells’ viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.

show abstract

“…97 Combining antibiotics with other methods such as adequate nutrition, proper dressing, and elimination of dead tissues can reduce the exogenous microbial infection. 98 However, the unnecessary exposure of the resident microflora to excessive antibiotics can lead to the formation of antibioticresistant strains. 99 Moreover, the antibiotic effect on pre-existing normal bacterial flora is difficult to control.…”

Section: Chemical Drugsmentioning

confidence: 99%

“…Topical application provides high and sustained concentrations of antibiotics to the wound site, which requires a low quantity of drugs compared with systemic therapy 97 . Combining antibiotics with other methods such as adequate nutrition, proper dressing, and elimination of dead tissues can reduce the exogenous microbial infection 98 . However, the unnecessary exposure of the resident microflora to excessive antibiotics can lead to the formation of antibiotic‐resistant strains 99 .…”

Section: Bioactive Moleculesmentioning

confidence: 99%

A review of current advancements for wound healing: Biomaterial applications and medical devices

2022

View full text Add to dashboard Cite

Wound healing is a complex process that is critical in restoring the skin's barrier function. This process can be interrupted by numerous diseases resulting in chronic wounds that represent a major medical burden. Such wounds fail to follow the stages of healing and are often complicated by a pro‐inflammatory milieu attributed to increased proteinases, hypoxia, and bacterial accumulation. The comprehensive treatment of chronic wounds is still regarded as a significant unmet medical need due to the complex symptoms caused by the metabolic disorder of the wound microenvironment. As a result, several advanced medical devices, such as wound dressings, wearable wound monitors, negative pressure wound therapy devices, and surgical sutures, have been developed to correct the chronic wound environment and achieve skin tissue regeneration. Most medical devices encompass a wide range of products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, and silk fibroin) and synthetic (e.g., polyvinyl alcohol, polyethylene glycol, poly[lactic‐co‐glycolic acid], polycaprolactone, polylactic acid) polymers, as well as bioactive molecules (e.g., chemical drugs, silver, growth factors, stem cells, and plant compounds). This review addresses these medical devices with a focus on biomaterials and applications, aiming to deliver a critical theoretical reference for further research on chronic wound healing.

show abstract

Drug-eluting wound dressings having sustained release of antimicrobial compounds

Cited by 30 publications

References 38 publications

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid

A review of current advancements for wound healing: Biomaterial applications and medical devices

Contact Info

Product

Resources

About