Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system

Prasher, Parteek; Sharma, Mousmee; Singh, Samarth Pratap

doi:10.1002/ddr.21754

Cited by 24 publications

(8 citation statements)

References 33 publications

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“…Amylose when modified with ethylene diamine and poly(methyl methacrylate (PMMA) via atom transfer radical polymerization (ATRP) technique induced switchable hydrophilicity and enhanced drug complexing ability. [28] Furthermore polysaccharide-capped metal nanoparticles with special reference to Amylose have been reported by Prasher et al [29] for delivery of antibiotics and anticancer drugs which ChemistrySelect possess poor availability and degrade easily due to cellular microbial efflux. Amylopectin is a dendritic component of starch with numerous hydroxyl groups conducive to chemical modifications favoring its use in gene and drug delivery.…”

Section: Starchmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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Section: Starchmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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“…Its characteristic properties such as biotolerance and nonimmunogenicity for human use, and easy availability make it a commonly used polymers/pharmaceutical excipient [254,255]. In comparison to other polymers such as gum and cellulose, starch does not need to undergo excessive purification, as they are relatively pure.…”

Section: Starchmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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“…Recent research has shown that the chlorotoxin (CTX) peptides increases the drug delivery efficacy together at SPION surface. [143][144][145]…”

Section: Biotherapeuticsmentioning

confidence: 99%

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

Aslam

Shukrullah

Naz

et al. 2021

Part & Part Syst Charact

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encountering non-target tissues, cells, or areas. [2] An overview of the general drug delivery system is given in Figure 1. Over four decades ago, the idea of "magnetized medication delivery" was proposed as a highly potential use of magnetic nanoparticles. Magnetic nanostructures are granules comprising of polymeric materials and medicine together with ferromagnetic components (magnetite). Substances utilized in the creation of nanostructures are sterilizable, harmless, and disposable; good examples include gelatin, ethyl cellulose, albumin, and collagen. [3] The idea of magnetostrictive aiming begins with linking active ingredients to magnetic nanocrystals accompanied by the infusion and assistance of these molecules to a target tissue under the impact of regionalized strong magnetic field and keeping there at site till the completion of the treatment and ultimate disposal. Literature shows six kinds of magnetic substances, i.e., antiferromagnetic, ferromagnetic, superparamagnetic, ferromagnetic, paramagnetic and diamagnetic. [4] The detail of these substances is given in Table 1. Once the external field is withdrawn, paramagnetic components shed magnetic momentum and super-paramagnetic substances turn nonmagnetic, unless an additional field is applied. [5] Nanomaterials may transport huge dosages of medicines to obtain great localized accumulation, preventing cytotoxic and other undesirable side symptoms occurring due to excessive dosing frequency in other regions of the body. In situ investigations showed that real clinical studies are a difficult job due to length management, durability, cytocompatibility, and adhesive coating for drug action as well as other physiologic characteristics. [3,6,7] The details of possible uses of magnetic nanoparticles (MNPs) in biomedical applications are given in Figure 2.The aim of creating or even strengthening administration methods is to deliver medicines to specific areas of the patient's system via a channel that can regulate the therapeutic distribution in terms of a physiologic or biochemical stimulus. Synthetic polymer-based microcapsules, microemulsions, and micelles are reported to be efficient in improving drug selectivity, reducing therapeutic toxicity, enhancing clinical oral bioavailability, and safety of medical products against biological degeneration. [15,16] Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applie...

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Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system

Cited by 24 publications

References 33 publications

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

Current-status and applications of polysaccharides in drug delivery systems

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

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