Drug eruption caused by enzalutamide: A case and literature review of androgen receptor inhibitor‐related drug eruptions

Abstract

Enzalutamide is an androgen receptor inhibitor. We report a new cutaneous eruption to this drug and review cases of drug eruptions caused by androgen receptor inhibitors.

Stevens-Johnson Syndrome Caused by Enzalutamide: A Case Report and Literature Review

“…We could only find two other cases of cutaneous adverse events to androgen receptor inhibitors in the English literature ( Table 1 ) ( 16 , 17 ). These two cases reported that skin lesions were noticed within two weeks after starting enzalutamide and were improved after hormone therapy.…”

“…The time of occurrence of cutaneous adverse events and the course of treatment were similar to our case, suggesting that cutaneous adverse events may occur during the early treatment period. The mechanism of enzalutamide-induced cutaneous adverse events is unknown, but it may be mediated by immunological mechanisms ( 16 ). One published case report of enzalutamide-induced thrombocytopenia observed a significant platelet count decline two weeks after starting enzalutamide, which recovered 30 days after enzalutamide withdrawal ( 18 ).…”

“…That being said, when the drug is an essential therapy, re-challenging or desensitization can be considered and attempted after evaluating the severity of ADRs and benefits-risks. In a published case report ( 16 ), enzalutamide was reinitiated at a low dose after the patient’s rash improved; however, a maculopapular eruption occurred within two days of therapy. The patient continued to receive enzalutamide treatment along with a topical application of betamethasone butyrate propionate ointment.…”

Phototoxic eruption caused by enzalutamide (Xtandi)

“…Photosensitive eruptions from flutamide 2 and bicalutamide 3 have been reported previously reported. Diffuse erythematous maculopapular eruption 4 and acute generalized exanthematous pustulosis 5 have been reported as skin rashes caused by enzalutamide. We have not found any case reported regarding a phototoxic eruption caused by this drug in the scientific literature.…”