Drug eruption due to entecavir: A case report and mini-review

Taura, Maiko; Asai, Jun; Cho, Zaigen; Wada, Makoto; Katoh, Norito

doi:10.1016/j.alit.2015.12.008

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…There are only a limited number of studies reporting cutaneous drug reactions associated with entecavir. The types of cutaneous drug eruptions associated with entecavir, including anaphylaxis (12), granulomatous (13), erythematous plaque (14), maculopapular (5,15), and bullous (our case), are summarized in Table 1. Our case presented with bullous drug eruptions, unlike other drug eruption cases, and surprisingly, it is the first case reported until now.…”

Section: Discussionmentioning

confidence: 99%

A case of entecavir-associated bullous fixed drug eruption and a review of literature

Temiz

Özer

Ataseven

et al. 2019

Turk J Gastroenterol

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Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the same site(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered to play a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Bullous FDE, on the other hand, is a relatively rare form of FDE. Hepatitis B is a significant worldwide health problem, and entecavir is a common nucleoside (deoxyguanosine) analog used for treating hepatitis B; however, it has various side effects, such as lactic acidosis, myalgia, azotemia, hypophosphatemia, headache, diarrhea, pancreatitis, and neuropathy, and, in rare cases, cutaneous drug eruption. Our aim is to present a case of entecavir-associated bullous drug reaction, which has not been reported in the literature. Furthermore, we performed a review of literature to compile previously reported entecavir-associated drug reactions.

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Section: Discussionmentioning

confidence: 99%