Drug-Facilitated Sexual Assaults

Ashok, J; Nair, Mohan; Friedman, Richard B.

doi:10.1007/978-1-4939-2416-5_5

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…150 Scopolamine may draw more attention in this regard due to a stronger sedation (than atropine) and overt amnestic effects, 150 which can promote sexual assault or violence. 151,152 Some cases of hypersexuality are described following intake of other drugs, such as clomipramine, with overt anticholinergic side effects. 153 Rodent literature supports the role of deliriants in the regulation of sexual behavior.…”

Section: Current Social and Cultural Impactmentioning

confidence: 99%

“…Representing naturally occurring aphrodisiacs, tropane alkaloids often stimulate libido but also cause toxicity in their users. , Presently, both atropine and scopolamine are included in some, but not all, studies of drugs facilitating sexual assault (DFSA) . Scopolamine may draw more attention in this regard due to a stronger sedation (than atropine) and overt amnestic effects, which can promote sexual assault or violence. , Some cases of hypersexuality are described following intake of other drugs, such as clomipramine, with overt anticholinergic side effects . Rodent literature supports the role of deliriants in the regulation of sexual behavior.…”

Section: Current Social and Cultural Impactmentioning

confidence: 99%

See 1 more Smart Citation

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Lakstygal

Колесникова

Khatsko

et al. 2018

ACS Chem. Neurosci.

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Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.

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