Drug Fever due to a Single Dose of Pantoprazole

Schiller, Dietmar; Maieron, A; Schöfl, R; Donnerer, Josef

doi:10.1159/000364781

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…Pancreatitis and peripheral edema have also been reported in human patients treated with pantoprazole ( 32 – 34 ). A case of pantoprazole-induced hyperthermia was reported in a human patient, however, none of our study goats had elevated temperatures during the study ( 35 ). While an investigation of adverse effects was beyond the scope of our present study, no gross adverse effects, such as edema or anaphylaxis were observed in this population.…”

Section: Discussionmentioning

confidence: 56%

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

et al. 2021

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Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats.Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats.Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis.Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr*μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study.Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be < that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats.

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Section: Discussionmentioning

confidence: 56%

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

et al. 2021

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“…A wide range of drugs can cause drug fever, but the most commonly associated are antibiotics, anticonvulsants and antiarrhythmic agents [1] . To our knowledge, only one case of drug fever associated with pantoprazole has been reported [3] .…”

Section: Discussionmentioning

confidence: 98%

Pantoprazole: An Unusual Suspect in a Patient with Fever

Melo

Policarpo

Dias

et al. 2021

European Journal of Case Reports in Internal Medicine

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Drugs can cause fever of unknown origin. Drug fever is a diagnosis of exclusion and can lead to unnecessary investigations and prolonged hospitalization. Any drug can be responsible. Here, we describe the case of a woman admitted because of acute hepatitis. Pantoprazole was started for stress ulcer prophylaxis when she was admitted to the ICU. Fever developed a few days later and an extensive diagnostic work-up was negative. Fever remitted after pantoprazole discontinuation and the diagnosis of drug fever was established.

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“…While these drugs have significant benefits to patients suffering from an acute UGIB, significant adverse effects can occur during both short and long-term therapy [6]. The adverse effects of long-term use that have been reported include increased risk of enteric infection, chronic atrophic gastritis, drug-induced lupus, acute interstitial nephritis, thrombocytopenia, and malabsorption of various nutrients like iron, vitamin B12, and magnesium [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Pantoprazole-Associated Thrombocytopenia: A Literature Review and Case Report

Phan¹,

Tseng²,

Choudhery³

et al. 2022

Cureus

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Proton-pump inhibitors (PPIs) are commonly utilized in the treatment of upper gastrointestinal bleeds (UGIBs) due to their ability to stabilize blood clot formation. PPIs have been shown to reduce rebleeding after endoscopic hemostasis and reduce signs of bleeding at index endoscopy. While PPIs are well-tolerated and commonly administered to patients suffering from acute UGIBs, significant adverse effects may occur. Patients have reported various mild systemic symptoms during short-term PPI use, including headache, rash, dizziness, nausea, abdominal pain, flatulence, constipation, and diarrhea. In general, serious side effects of PPIs tend to be mild during treatment periods under two weeks; however, as the treatment duration increases, side effects have been observed to increase in frequency and severity. PPI-induced thrombocytopenia is an exceedingly rarely reported adverse reaction that remains largely unstudied due to the dearth of patient cases. This adverse effect continues to be a diagnosis of exclusion, and there are no current evidence-based recommendations to approach this complication. Thrombocytopenia increases the risk of rebleeding and hemodynamic instability, which may be devastating to patients suffering from UGIBs. Here, we present a case of thrombocytopenia that began after the introduction of pantoprazole in the setting of a UGIB. The thrombocytopenia resolved promptly after cessation of the medication. We highlight this case to increase awareness of this rare finding given the lack of recommendations for short-term PPIinduced thrombocytopenia.

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Drug Fever due to a Single Dose of Pantoprazole

Cited by 12 publications

References 10 publications

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

Pantoprazole: An Unusual Suspect in a Patient with Fever

Pantoprazole-Associated Thrombocytopenia: A Literature Review and Case Report

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