Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient

Li, Zheng; Shen, Jianxiong; Li, Qiyi; Chan, Matthew T. V.; Wu, William Ka Kei

doi:10.1097/md.0000000000001875

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Based on previous reports, the diagnostic criteria for DF include the following [Young 1982;Pleasants 1994]: (1) a temperature above 37.5°C; (2) no signs of infection after detailed examinations; (3) return of the temperature to normal after drug discontinuation within 48 hours to 72 hours; (4) rapid increases in body temperature after administration of the drug (namely the drug provocation test (DPT) is positive); (5) exclusion of other possible causes of fever. It is still difficult to diagnose DF through the [Park 2011;Li 2015]. If necessary, DPT should be performed after the patients have been informed of adverse effects that may occur during the test.…”

Section: Discussionmentioning

confidence: 99%

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Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Yang

Wang

et al. 2019

HSF

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Introduction: Drug fever is a febrile reaction caused by initiation of one drug or varieties of drugs and often disappears after cessation of the drug(s). Clinically, drug fever is frequently induced by antibiotics, anticonvulsants, and antineoplastics. There are few previous reports about drug fever caused by imipenem/cilastatin. Case Presentation: Here, we described a 66-year-old man undergoing the Ivor Lewis esophagectomy for esophageal carcinoma, who developed drug fever. The patient had a high temperature with shivering after administration of imipenem/cilastatin for 7 days. Furthermore, his temperature came down after discontinuing imipenem/cilastatin and receiving steroids. Body temperature increased rapidly 4 hours after intravenous readministration of imipenem/cilastatin and rapidly decreased to normal after discontinuing imipenem/cilastatin and administering steroids. Conclusion: Thorough history, blood tests, physical examination, and computed tomography (CT) did not reveal any evidence of fever. Drug fever caused by imipenem/cilastatin was considered. We also present a review of relevant literature and provide a point of reference for the clinical diagnosis and therapy of patients with drug fever.

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Section: Discussionmentioning

confidence: 99%

“…Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature: A Case Report-Yang et alE121© 2019 Forum Multimedia Publishing, LLC aforementioned diagnostic criteria, especially when it overlaps with the course of anti-infection therapy[Li 2015]. out.…”

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confidence: 99%

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Yang

Wang

et al. 2019

HSF

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“…There were few case reports about drug fever due to piperacillin/tazobactam with other comorbidities. One case was reported of a patient who underwent scoliosis correction surgery in China5 and another patient with antibiotic-loaded bone cement from Korea 6. In these cases, drug fever was associated with rash and/or eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

Drug fever induced by piperacillin/tazobactam in an elderly patient with underlying human immunodeficiency virus (HIV) infection

2016

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Our search of the literature revealed no detailed case reports about drug fever induced by piperacillin/tazobactam in a patient with HIV infection although there were a few case reports about drug fever due to piperacillin/tazobactam with other comorbidities. A 63-year-old male patient with HIV positive was admitted for acute cholecystitis. He was started on piperacillin/tazobactam. For the next 8 days, he had intermittent fever up to 103°F (39.4°C) with relative bradycardia although he showed clinical improvement. There was no laboratory or imaging findings suggestive of another infectious source and drug fever was suspected. The antibiotics were stopped and after 48 hours no fever was observed until the day of discharge. Piperacillin/tazobactam can induce fever in patients with cystic fibrosis and in patients with other conditions. Drug fever may be more prevalent in patients with HIV infection. It has no characteristic pattern and may not be associated with eosinophilia.

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“…However, history, X-ray chest, blood cultures, physical examination, and urinalysis revealed no evidence of fever. (12) Incorrect blood component transfusion resulting in hemolytic transfusion reactions and transfusion related acute lung injury (TRALI) remain major sources of morbidity and mortality. Febrile transfusion reactions are defined as 1° Celsius increase in temperature during or within 3 hours of transfusion that cannot be explained by sepsis or hemolytic transfusion reaction.…”

Section: Causesmentioning

confidence: 99%

Postoperative Fever

2017

SUJHS

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Fever is one of the most common and treatable cause of morbidity. Though mostly benign, it can sometimes lead to a fulminant and malignant course. Postoperative fever has greatly perplexed the treating physician due to its varied etiologies. If not timely evaluated, it can lead to waste of health resources and increased health care cost. In the present article, we will be discussing the important causes of fever and their treatment.

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Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient

Cited by 9 publications

References 12 publications

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Drug fever induced by piperacillin/tazobactam in an elderly patient with underlying human immunodeficiency virus (HIV) infection

Postoperative Fever

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