Drug-Induced Acute Interstitial Nephritis Mimicking Acute Tubular Necrosis after Initiation of Tenofovir-Containing Antiretroviral Therapy in Patient with HIV-1 Infection

Abstract

We describe a case of 68-year-old Japanese man with HIV-1 infection who developed acute kidney injury with prominent tubular dysfunction immediately after starting tenofovir-containing antiretroviral therapy. Antiretroviral therapy was discontinued in two weeks but renal function, as well as tubular function, did not shown full recovery even at a 3-year follow-up examination. Acute tubular necrosis, a rare but well-known side effect of tenofovir, was suspected, but kidney biopsy confirmed interstitial nephritis. It is important to distinguish drug-induced interstitial nephritis from acute tubular necrosis, because early steroid administration can improve renal dysfunction caused by acute interstitial nephritis.

Construção e validação de cartilha educativa com enfoque na saúde e qualidade de vida das pessoas vivendo com o HIV/aids

“…câncer (HIRSCHHORN et al, 2012); doença renal (NISHIJIMA et al, 2012;PECK et al, 2014); doença hepática (PUOTI et al, 2012;SORIANO;BARREIRO;SHERMAN, 2013);neurocognitiva (BRITO;GANNON;KHAN;KOLSON, 2011;GRANT et al, 2014); osteopenia ou osteoporose (MUNDY et al, 2012;YOUNG et al 2011); e depressão (CHOI et al, 2016;GONZALEZ et al, 2011;NYIRENDA et al, 2013) (coletivamente referidos como eventos graves de não-aids) (DEEKS; LEWI; HAVLIR, 2013).…”