Drug-Induced Acute Pancreatitis After Long-Term Sulfasalazine Therapy

Abstract

The list of drugs associated with acute pancreatitis is increasing with each passing year. Nevertheless, knowledge of drug-induced pancreatitis (DIP) are often curtailed by the limited availability of evidence needed to implicate given agents, especially for non-prescription medications. Indeed, the majority of available data are derived from case reports, case series, or case-control studies. We present a case chemically and radiologically proven pancreatitis in a 43-year-old female who was on sulfasalazine as a maintenance therapy for ulcerative colitis.

Efficacy and safety of Chinese patent medicine combined with 5-aminosalicylic acid for patients with ulcerative colitis: A network meta-analysis of randomized controlled trials

“…Although 5-ASA medications have proven clinical efficacy, some of them can cause serious side effects. For instance, sulfasalazine has been associated with drug eruptions, drug-induced hypersensitivity syndrome, and acute pancreatitis [ [4] , [5] , [6] ]. Salicylic acid preparation and immunosuppressive therapy won't cause any effective effects on some patients [ 7 ].…”