Drug-induced acute pancreatitis: results from the hospital-based Berlin case-control surveillance study of 102 cases

Abstract

SUMMARY BackgroundDrug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown.

ACE inhibitors and the risk of acute pancreatitis—a population‐based case–control study

“…The findings were more pronounced among apparently healthy users, yet similar among current users and those with no history of gallstone or alcohol‐related diseases. Our findings are in accordance with the results of three other case–control studies and one cohort study …”

Tocilizumab-induced pancreatitis: case report and review of data from the FDA Adverse Event Reporting System

“…Patient data collection for AE was performed by the Berlin Case–Control Surveillance Study (FAKOS), which looked at serious AE of drugs such as AP and other serious diseases between 2000 and 2011. Details of FAKOS have been previously published . Patients included in the pancreatitis part of FAKOS had to be at least 18 years old and meet two of the three following criteria: elevation of lipase or amylase at least 3‐fold above the upper limit of normal (ULN), characteristic upper abdominal pain or signs of AP in imaging .…”

“…Details of FAKOS have been previously published . Patients included in the pancreatitis part of FAKOS had to be at least 18 years old and meet two of the three following criteria: elevation of lipase or amylase at least 3‐fold above the upper limit of normal (ULN), characteristic upper abdominal pain or signs of AP in imaging . Exclusion criteria included diagnosis of chronic pancreatitis, biliary pancreatitis, prior history of biliary colic, dilated biliary tract or concomitant rise of bilirubin and transaminases, other known aetiologies of AP, such as obstructions by tumours or pancreatic malformations, alcoholism, ischaemic or trauma‐induced AP, hyperparathyroidism, massive hypertriglyceridaemia (>11·2 mmol/L; ≈1000 mg/dL) or an endoscopic retrograde cholangiopancreatography in the last 48 h before onset of the symptoms …”

Case of drug-induced acute pancreatitis produced by horsetail infusions

“…Drug-induced pancreatitis is usually edematous type and not clinically severe (3), nor lead to a multiorgan failure (7). It presents like any other pancreatitis with abdominal epigastric pain radiating to the back and amylase above three times its normal value (3,7,9).…”

“…It presents like any other pancreatitis with abdominal epigastric pain radiating to the back and amylase above three times its normal value (3,7,9). It is not usually accompanied by rash, lymphadenopathy and/or eosinophilia, as other diseases caused by toxins (5).…”