Drug-induced crystal nephropathy: an update

Yarlagadda, Sri G.; Perazella, Mark A.

doi:10.1517/14740338.7.2.147

Cited by 123 publications

(146 citation statements)

References 85 publications

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“…Crystals ( Figure 37 Comment: Administered compounds or their metabolites may precipitate in the urine filtrate, particularly if they are of low solubility and/or in high plasma concentration with a high percentage of renal clearance (Yarlagadda and Perazella 2008). Because of the concentration of urine and hypertonicity in the distal tubular segments, especially in the rat, crystalluria is more common in this region (Hagiwara et al 1992).…”

Section: Differential Diagnosesmentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

et al. 2012

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the urinary tract of rats and mice. The standardized nomenclature of urinary tract lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for urinary tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Differential Diagnosesmentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

et al. 2012

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“…This anti-folate and its metabolites precipitate within the renal tubular lumens in the setting of low urine pH, decreased urinary flow rates from volume depletion and with high urinary methotrexate concentrations [17]. High-dose methotrexate causes kidney injury through multiple possible mechanisms; however, intratubular crystal precipitation is the most likely [18][19][20]. Diagnosis is suggested when AKI develops in the clinical scenario described and may be supported by visualization of urinary methotrexate crystals (FIGURE 1C).…”

Section: Thrombotic Microangiopathymentioning

confidence: 99%

Review of select causes of drug-induced AKI

Perazella

Luciano

2015

Expert Review of Clinical Pharmacology

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“…Indinavir presently plays a minor role in cART regimens because of its mode of administration (800 mg three times daily on an empty stomach) and side effect profile demonstrated in earlier trials, mainly a substantial risk for nephrolithiasis [15] and mucocutaneous events similar to retinoid therapy such as alopecia, dry skin [16] and lips, and ingrown nails.…”

Section: Indinavirmentioning

confidence: 99%

Toxicity of HIV protease inhibitors: clinical considerations

Boesecke

Cooper

2008

Current Opinion in HIV and AIDS

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Protease inhibitors are still a cornerstone of combination antiretroviral therapy. A profound knowledge of the unwanted, but manageable, effects of protease inhibitor therapy is required to maintain an otherwise efficient and well tolerated antiretroviral therapy. Further research will elucidate the potential role of protease inhibitors both in double-boosted salvage therapy and in resource-limited settings.

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Drug-induced crystal nephropathy: an update

Cited by 123 publications

References 85 publications

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

Review of select causes of drug-induced AKI

Toxicity of HIV protease inhibitors: clinical considerations

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