Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Bai, Chunfeng; Padma, L; Mohan, Niveditha; Veena, D R

doi:10.5455/2319-2003.ijbcp20140830

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Highly occurring ADR in present study was rashes, which is similar to results obtained in other studies like Dimple Gohel et al, Ghosh S et al 17,18 However some other studies from India reported Fixed Drug Eruption to be the most common type of ACDR Pudukadan D et al 14 In our study, cutaneous adverse drug reactions were most commonly observed with NSAIDS (37%), followed by antimicrobials (22.2%) and antiepileptics (14.8%). Few studies have reported that NSAIDS were the main group of drugs to cause different types of skin reactions, thus supporting our study Bai CK et al, Sharma VK et al, 19,11 Other studies show that the most offending drugs were antimicrobials Chatterjee et al 4 Among the 11 cases of Rash, 5 cases were due to NSAIDS (45.4%), 2 cases were due to antimicrobials (18.1%), 2 cases were due to antiepileptics(18.1%), 1 case was due to antipsychotic (9%), and 1 case was due to antacid (9%).Among 4 cases of Urticaria, 1 case was due to NSAIDS (25%), 1 case was due to hormone (25%), and 1 case was due to iron sucrose inj. (25%), 1 case was due to tetanus toxoid (25%).Among 4 cases of Fixed drug eruption, 3 cases were due to NSAIDS (75%), 1 case was due to antimicrobial (25%).…”

Section: Discussionsupporting

confidence: 91%

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Ciddhavaduta¹,

Samikrutha²,

Baloju³

2018

jebmh

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BACKGROUND Drugs can cure, suppress or prevent a disease and are usually beneficial to humans. However, they can also produce undesirable or harmful effects, which are known as adverse drug reactions (ADR). Understanding the nature of ACDRs may help narrow down the search for the offending agent. The need for this study is for early diagnosis, to reduce the morbidity and mortality due to ACDR and to ensure safety of the patients. MATERIALS AND METHODS The present study was carried out at Bhaskar general hospital under ICMR project, Department of Dermatology where in 27 patients of ADR were enrolled to establish the aetiologic agent for a particular type of reaction, attention was paid to the drug history, temporal correlation with the drug, duration of rash, approximate incubation period, morphology of the eruption, associated mucosal or systemic involvement, improvement of lesion on withdrawal of drug and recurrence of lesion on rechallenge. RESULTS This study showed that the incidence of ACDRs were more in males 55.5% than in females 44.5%. Most of the Cutaneous ADRs were probable in type under causality assessment and moderate under severity assessment. The presentation of cutaneous ADR was in the form of rash, urticaria, fixed drug eruption. Drugs causing these included NSAIDS, Antiepileptic's and antimicrobials. CONCLUSION Effective strategy to prevent the occurrence of ADRs is always preferred. Some of the measures that may reduce the occurrence of cutaneous ADRs are listed below. Avoid polypharmacy. Prescribe drugs, which have been known to cause cutaneous ADRs, only if extremely necessary. Obtain history of skin reactions in the past. Educate the patients regarding common early symptoms of drug reactions (e.g. erythematous rash, oedema, urticaria, mucosal erosions, itching, burning of skin etc.) especially during start of a therapy.

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Section: Discussionsupporting

confidence: 91%

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Ciddhavaduta¹,

Samikrutha²,

Baloju³

2018

jebmh

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“…45 (37.5%) patients had a previous history of cutaneous ADRs to drugs. Bai [10] reported a past history of ADRs in six (10%) patients. Positive history of allergic disorders like atopic dermatitis, contact dermatitis, allergic rhinitis, bronchial asthma and urticaria was noticed in 34 (28.3%) patients.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital

Amrinder¹,

Kaur²

2016

J Pharmacovigil

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Introduction: Cutaneous adverse drug reactions (ADRs) are the most frequently occurring ADRs to drugs. These reactions have a varied morphology and are responsible for significant mortality and morbidity. The aim of this study is to characterize the morphological patterns of cutaneous ADRs and to determine the incriminating agents. Method: The study was carried out in the Dermatology, Venereology and Leprosy department, Guru Nanak Dev Hospital, Government Medical College, Amritsar from 1 st March 2014 to 31 st May 2015. World Health Organization-Uppsala monitoring centre (WHO-UMC) causality scale was used to determine the causality of cutaneous ADRs and severity was assessed using Hartwigs severity scale. Results: In the present study, the highest incidence of cutaneous ADRs was in the age group of 31-40 years (25.0%), and more frequently in female patients (54.2%). Antimicrobials were the most commonly implicated drugs (37.5%) followed by Non-Steroidal Anti-inflammatory drugs (NSAIDs) (25.0%), various combination drugs (10.0%), corticosteroids and antiepileptics (6.6%). The most commonly observed morphological pattern was of Fixed drug eruptions (33.3%) followed by maculopapular rash (30.8%) and Steven Johnson Syndrome (5.8%). Causality assessment was certain, probable and possible for 1.6%, 93.3% and 41.5% of the reactions, respectively. 109 cases were of level 3 severities, 10 cases to level 4 severities and one case of level 7 where ADR was responsible for death in one patient. Discussion: Most of the adverse drug reactions are preventable, provided the drugs are used rationally. Antimicrobials were the most common causative group and fixed drug eruption was the most frequently encountered morphological pattern. Therefore it is imperative that in each patient the risk of drug administration should be weighed against the expected therapeutic benefit.

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Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Cited by 2 publications

References 12 publications

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Analysis of Cutaneous Adverse Drug Reactions on Using Commonly Prescribed Drugs at a Tertiary Care Hospital

Monitoring of Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital

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