Drug induced diseases (DID): Need for more awareness &amp; research

Adithan, C; Selvarajan, Sandhiya

doi:10.4103/0971-5916.162086

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…We had a much higher percentage of males in the study compared to the females (70.2% vs. 29.8%). A few other hospital based studies from India suggest a similar trend [21, 22]. This could be due to males spending more time outdoors in the conservative Indian society or due to differential seeking of medical care by different sexes or due to biological differences in the sexes to dengue virus.…”

Section: Discussionmentioning

confidence: 77%

Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India

Changal

Raina

et al. 2016

BMC Infect Dis

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BackgroundSecondary dengue causes more severe disease than the primary. Early on, it is important to differentiate the two. We tried to find important clinical and laboratory differences between the two for the purpose of early differentiation.MethodsOne hundred fourteen patients confirmed on reverse transcriptase-polymerase chain reaction (RT PCR) were studied. On day 2 of illness IgM and IgG indices were studied for calculation of IgG/IgM ratio. A one-step immunochromatographic assay was used for classification of patients into primary and secondary dengue. Patient characteristics were also studied.ResultsDengue serotype 1 was the most common found in 60.5% patients. 66.7% (76 patients) had secondary dengue. Secondary dengue cases had a higher mean temperature (101.56 ± 1.55 vs. 100.79 ± 1.25,°F, p 0.015), lower platelet counts (50.51 ± 38.91 vs. 100.45 ± 38.66, x 103/micl, p <0.0001) and a significantly higher percentage of Dengue hemorrhagic fever/Dengue shock syndrome (38.2% vs. 2.6%, p <0.0001). In early phase of dengue NS1 and PCR were found to be better tests for diagnosis and later IgM is better. The IgG/IgM ratio of ≥ 1.10 had a sensitivity of 100%, specificity of 97.4% and accuracy of 67.5% in differentiating secondary from primary dengue.ConclusionEarly on in the clinical course, IgG/ IgM ratio can play an important role to differentiate the two. We found the ratio of ≥ 1.10 to be the best cut off for the same.

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Section: Discussionmentioning

confidence: 77%

Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India

Changal

Raina

et al. 2016

BMC Infect Dis

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show abstract

“…The true incidence or prevalence of DID in our country is not known and the same is also not reflected in our study. In the commentary by Adithan et al 2 on our article, it has already been pointed out our study 1 has an overlap between adverse drug reactions (ADR) and DID, yet it flags an important issue which needs attention by the health care providers. We have already admitted in the limitations of the study that true prevalence of the DIDs cannot be computed due to voluntary/spontaneous nature of reporting which is an inherent part of standard operating procedure of Pharmacovigilance Programme of India (PvPI).…”

mentioning

confidence: 81%