Drug-induced disorders of the small bowel

Perforation of Jejunal Diverticula in Steroids and Nonsteroidal Anti‐Inflammatory Drug Abusers: A Case Series

“…Long-term NSAID therapy usually induces clinically silent enteropathy characterized by increased intestinal permeability and inflammation [9]. The small bowel is thus exposed to the local and the systemic actions of the NSAIDs, mainly interfering with the prostaglandin synthesis, which is important in maintaining mucosal integrity [10]. In patients with diverticular disease, NSAID use increases the risk of severe diverticular infection and perforation.…”