Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

Zhu, Weifang; Fang, De-ren; Fang, Hong

doi:10.5847/wjem.j.1920-8642.2021.04.008

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…ALA intoxication can also cause anaphylactic shock. 9 Erythroderma due to drugs manifests as generalized exfoliative dermatitis and classified as severe drug reaction. Drugs that can trigger erythroderma include antiviral, antituberculosis, sulfamethoxazole, carbamazepine, traditional Chinese medicines, antibiotics, immune checkpoint inhibitors and thalidomide.…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood abnormality in Sezary Syndrome with bacteremia

et al. 2022

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Introduction: Sezary syndrome defined as a set of symptoms consist of erythroderma, generalized lymphadenopathy, and Sezary cells were detected in peripheral blood, skin and lymph nodes. Case: Patients with chief complaints red and scaly patches cover almost part of the body accompanied by itching since 1 week ago. The patient had history of taking herbal medicines 2 weeks earlier. There is an erosion and crusting at inferior lips. There is also fissure at left side ventral hand region. There is no generalized lymphadenopathy. The patient has fever, hypertension and hyperglycemia. The laboratory result showed leukocytosis with Sezary cells > 1000 cells/mm3, and bacteremia (coccus). Differential diagnosis of patients was Sezary syndrome, drug-induced erythroderma and mycosis fungoides. The diagnosis was Sezary syndrome because erythroderma and Sezary cells > 1000 cells/ mm3 were found. The patient was treated with injection of corticosteroid, antibiotic, barrier repair moisturizer and potent topical corticosteroid. Conclusion: Sezary syndrome is often accompanied by bacteremia due to impaired skin barrier function and decreased cellular immunity. Examination of biopsy, bacterial culture and flow cytometer is required for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Peripheral blood abnormality in Sezary Syndrome with bacteremia

et al. 2022

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“…In addition, Mathew and Sreedevan observed drug-induced erythroderma in 6.5% of cases [6]. Drug-induced erythroderma may occur days or weeks after exposure, and it evolves quickly [1,15,16]. The number of drugs can be the causative factor [1,2].…”

Section: Drug Reactionmentioning

confidence: 99%

Erythroderma: A Retrospective Study of 212 Patients Hospitalized in a Tertiary Center in Lower Silesia, Poland

Kliniec,

Snopkowska,

Łyko

et al. 2024

JCM

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Erythroderma is a condition characterized by erythema affecting at least 90% of the skin surface area. It can be caused by various underlying conditions. Due to nonspecific clinical and laboratory findings, determining the cause may pose a challenge. In the retrospective study, we identified 212 patients hospitalized for erythroderma in the Department of Dermatology, Venereology, and Allergology at Wroclaw Medical University between January 2012 and March 2022. Clinical, laboratory, and histopathological features, as well as the management of patients, were studied. The median age of adults was 61 years (IQR = 47–68). The most common causes of erythroderma were psoriasis (n = 49, 24.01%), followed by atopic dermatitis (AD) (n = 27, 13.23%), and cutaneous T-cell lymphomas (CTCL) (n = 27, 13.23%). Despite laboratory tests and histopathological examination, the etiology of erythroderma remained undetermined in 39 cases (19.12%). In 70.59% of patients, it was the first episode of erythroderma, while 29.41% experienced a recurrent episode. Regardless of the etiology of erythroderma, patients were most frequently treated with systemic antihistamines (146 cases, 71.57%) and systemic steroids (132 cases, 64.71%). Patients with idiopathic erythroderma constitute the greatest diagnostic and therapeutic challenge, requiring particularly thorough evaluation.

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“…There is pruritus, scaling, fever, lymphadenopathy, and visceral enlargement. Occasionally, edema, hyperkeratosis and mucosal involvement may be present [40,[45][46][47]. Histopathology shows hyperkeratosis, parakeratosis, acanthosis, and chronic inflammatory infiltrates surrounding blood vessels with eosinophils [40].…”

Section: Drug-induced Erythroderma or Exfoliative Dermatitis (Ed)mentioning

confidence: 99%

“…Histopathology shows hyperkeratosis, parakeratosis, acanthosis, and chronic inflammatory infiltrates surrounding blood vessels with eosinophils [40]. Drugs like-antivirals, antibiotics, carbamazepine, thalidomide [46] and NSAIDs [48] may cause ED. Among antimicrobials, common culprits are sulfonamides, antimalarials, penicillins, isoniazid, thioacetazone, and streptomycin [40,48].…”

Section: Drug-induced Erythroderma or Exfoliative Dermatitis (Ed)mentioning

confidence: 99%

Untitled

2023

JOJDC

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Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently.

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Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

Cited by 7 publications

References 20 publications

Peripheral blood abnormality in Sezary Syndrome with bacteremia

Peripheral blood abnormality in Sezary Syndrome with bacteremia

Erythroderma: A Retrospective Study of 212 Patients Hospitalized in a Tertiary Center in Lower Silesia, Poland

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