Drug-induced gingival overgrowth

Dongari, Anna; McDonnell, Howard T.; Langlais, Robert P.

doi:10.1016/0030-4220(93)90027-2

Cited by 91 publications

(59 citation statements)

References 30 publications

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“…Often the presence of dense, fibrous gingival tissues prevents exfoliation of primary teeth and failure of secondary tooth eruption, resulting in malocclusion. Several types of medications (calcium channel blockers, cyclosporin, and phenytoin) have also been associated with gingival fibromatosis, yet not everyone exposed to these medications develops gingival overgrowth, suggesting genetic determinants of susceptibility (Hassell and Hefti, 1991;Dongari et al, 1993 (Heikinheimo et al, 1989;Aberdam et al, 1994;Heikinheimo and Salo, 1995). However, because of the unique characteristics of the oral epithelium, the oral mucosa may or may not display fragility similar to that of the skin.…”

Section: Genetic Abnormalities Affectingmentioning

confidence: 99%

The Impact of Molecular Genetics on Oral Health Paradigms

Hart

Marazita

Wright

2000

Critical Reviews in Oral Biology & Medicine

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As a result of our increased understanding of the human genome, and the functional interrelationships of gene products with each other and with the environment, it is becoming increasingly evident that many human diseases are influenced by heritable alterations in the structure or function of genes. Significant advances in research methods and newly emerging partnerships between private and public sector interests are creating new possibilities for utilization of genetic information for the diagnosis and treatment of human diseases. The availability and application of genetic information to the understanding of normal and abnormal human growth and development are fundamentally changing the way we approach the study of human diseases. As a result, the issues and principles of medical genetics are coming to bear across all disciplines of health care. In this review, we discuss some of the potential applications of human molecular genetics for the diagnosis and treatment of oral diseases. This discussion is presented in the context of the ongoing technological advances and conceptual changes that are occurring in the field of medical genetics. To realize the promise of this new molecular genetics, we must be prepared to foresee the possibilities and to incorporate these newly emergent technologies into the evolving discipline of dentistry. By using examples of human conditions, we illustrate the broad application of this emerging technology to the study of simple as well as complex genetic diseases. Throughout this paper, we will use the following terminology: Penetrance In a population, defined as the proportion of individuals posessing a disease-causing genotype who express the disease phenotype. When this proportion is less than 100%, the disease is said to have reduced or incomplete penetrance. Polymerase chain reaction (PCR)-A technique for amplifying a large number of copies of a specific DNA sequence flanked by two oligonucleotide primers. The DNA is alternately heated and cooled in the presence of DNA polymerase and free nucleotides, so that the specified DNA segment is denatured, hybridized with primers, and extended by DNA polymerase. MIM-Mendelian Inheritance in Man catalogue number from V. McKusick's Mendelian Inheritance in man (OMIM, 1998).

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Section: Genetic Abnormalities Affectingmentioning

confidence: 99%

The Impact of Molecular Genetics on Oral Health Paradigms

Hart

Marazita

Wright

2000

Critical Reviews in Oral Biology & Medicine

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“…Although the exact role played by dental plaque in drug induced gingival enlargement is unclear, there is evidence that good oral hygiene and frequent professional removal of plaque decreases the degree of gingival enlargement present and improves overall gingival health. 31 The possibility of discontinuing the offending drugs or of changing the medication should be raised. 32 Discontinuation of the drug usually results in complete regression of the gingival overgrowth.…”

Section: Discussionmentioning

confidence: 99%

Verapamil induced gingival enlargement in cluster headache

Matharu

Vliet²,

Ferrari³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

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“…Bu nedenle tedavideki ilk basamak hastanın ilacının müm-künse büyüme yapmayan başka bir ilaçla değiştirilmesi olmalıdır. 22,23 Bu tedavi yaklaşımı ile gingival lezyonların çözülmesi 1-8 hafta sürebilir. Ancak hastaların çoğu bu tedavi yöntemine cevap vermemiştir.…”

Section: Ancakunclassified

Kalsi̇yum Kanal Blokörü (Amlodi̇pi̇n) Kullanimina Bağli Di̇şeti̇ Büyümesi̇: 5 Yil Taki̇pli̇ Vaka Raporu

KURGAN¹,

Önder²,

TAYMAN³

et al. 2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZHipertansiyon, anjina pektoris ve kardiyak aritmi gibi kardiyovasküler problemlerin tedavisi için sıklıkla kullanılan ilaçlardan olan kalsiyum kanal blokörlerinin, yan etki olarak dişeti büyümesine neden oldukları bilinmektedir. Kalsiyum kanal blokörü olan amlodipin, hipertansiyon tedavisinde antihipertansif bir ilaç olarak kullanılmaktadır. Yapılan birçok çalışmada, amlodipinin de diğer kalsiyum kanal blokörleri gibi dişeti büyümesini tetiklediği gösterilmiştir. Bu vakada amlodipin kullanımına bağlı gelişen dişeti büyümesinin ağız içi klinik özellikleri ve tedavi protokolleri sunulmuştur. Hipertansiyon tedavisi için 3 yıldır amlodipin kullanan 77 yaşındaki kadın hasta, üst çenesinde estetik ve fonksiyonel problemlere neden olan aşırı dişeti büyümesi şikâyeti ile kliniğimize başvurmuştur. Tedavisinde; kazıma ve kök yüzey düzlemesi işlemi, ilacın değiştirilmesi, cerrahi eksizyon ve klinik sonucun idame ve destekleyici tedavisi yapılmıştır. İlaca bağlı dişeti büyümelerinin tedavisi, ilacı kesme ya da başka bir ilaçla değiştirme ve dikkatli bir şekilde mekanik ve kimyasal olarak plak kontrolü ile risk faktörlerinin azaltılmasını içerir. Oral hijyeni ve fonksiyonu etkilemesi veya kozmetik nedenlerle, aşırı dişeti büyümesi görülen şiddetli vakalar eksize edilmelidir. Diş hekimlerinin kalsiyum kanal blokörü kullanan bireylerde dişeti büyümesi riski açısından dikkatli olmaları ve iyi plak kontrolü yapabilmeleri için hastalarını eğitmeleri önemlidir. Anahtar kelimeler: Dişeti büyümesi, kalsiyum kanal blokörü, hipertansiyon, amlodipin ABSTRACT Calcium channel blockers are among the most widely used drugs in the treatment of cardiovascular problems such as hypertension, angina pectoris and cardiac arrhythmia. These drugs cause gingival overgrowth as a side effect. Amlodipine is one of the calcium channel blocker, which is used to treat hypertension. Many studies have been shown that, amlodipine triggers gingival growth as other calcium channel blockers. In this case, the clinical features and developing treatment protocols of gingival enlargement due to use of amlodipine have been presented. A 77-years-old female patient who has used amlodipine for 3 years for hypertension referred to our clinic with the complain of maxillary massive gingival overgrowth causing functional and esthetic problems. The treatment aspect included scaling and root planning (SCRP), substitution of the drug, the surgical excision and the maintenance and supportive therapy resulting in excellent clinical outcome. Treatment of drug-induced gingival overgrowth includes cessation or replacement of the drug and decreasing other risk factors with meticulous mechanical and chemical plaque control. Excision of excessive gingival tissue should be reserved for severe cases that affect oral hygiene or functionality, or can be performed for cosmetic reasons. It is important that dentists are aware that individuals taking calcium channel blockers need to demonstrate excellent plaque control to reduce their risk of developing gingival overgrowth.

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Drug-induced gingival overgrowth

Cited by 91 publications

References 30 publications

The Impact of Molecular Genetics on Oral Health Paradigms

The Impact of Molecular Genetics on Oral Health Paradigms

Verapamil induced gingival enlargement in cluster headache

Kalsi̇yum Kanal Blokörü (Amlodi̇pi̇n) Kullanimina Bağli Di̇şeti̇ Büyümesi̇: 5 Yil Taki̇pli̇ Vaka Raporu

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