Drug-induced gynecomastia

Eckman, Ari; Dobs, Adrian S.

doi:10.1517/14740330802442382

Cited by 52 publications

(48 citation statements)

References 99 publications

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“…In some cases, gynecomastia is the result of hormonal disorders caused by exogenous factors such as chronic alcoholism, where the levels of circulating testosterone and the clearance of estrogens are altered, or different classes of drugs [5,8]. It is also worth remembering those cases of gynecomastia deriving from unusual causes such as the use of highly estrogen-containing creams or those cases resulting from the consumption of meat from animals fed with estrogen by-products [7,9].…”

Section: Pathogenesismentioning

confidence: 99%

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules

et al. 2012

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Gynecomastia is a pathological enlargement of male breasts due to hormonal imbalance and elevation of estrogens at the expense of testosterone. It is very important to diagnose this disease precociously because it can be the expression of different underlying pathologies. Besides genetic, chromosomal or chronic diseases, drugs often represent the principal cause of this hormonal disequilibrium. In the elderly population, antiandrogen therapy for prostate cancer frequently induces gynecomastia, thus negatively affecting the patients’ compliance to treatment because of physical and psychological discomfort deriving from this condition; gynecomastia can in fact be associated with severe breast pain, and it can modify how patients see their own body. During the past decades and even today, many different surgical, radiotherapeutic or clinical approaches have been proposed to prevent or treat this hypertrophy. This article focuses on gynecomastia associated with antiandrogen-based hormonal treatment and shortly reviews the currently most often used therapeutic options for preventing and treating this pathology.

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Section: Pathogenesismentioning

confidence: 99%

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules

et al. 2012

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“…Gynecomastia often occurs in newborn and pubescent boys [5] . However, drug-induced gynecomastia is much more common in adults than in children and adolescents [6] .…”

Section: Discussionmentioning

confidence: 99%