Drug-induced hypersensitivity syndrome: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease

Kawakami, Tamihiro; Fujita, Atsuko; Takeuchi, Sora; Muto, Shinji; Soma, Yoshinao

doi:10.1016/j.jaad.2008.07.044

Cited by 25 publications

(9 citation statements)

References 14 publications

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“…There are also some reports of positive drug PTs in patients with DRESS 2 in response to abacavir, 18 antituberculous agents, 19 aspirin, 20 carbamazepine, 17,21 cyclins, beta‐lactam antibiotics, 9,22 celecoxib, 19 esomeprazole, 22 fluindione, 23 lamotrigine, 2 phenytoin, 3 propylthiouracil, 24 spironolactone and topiramate 3 …”

Section: Discussionmentioning

confidence: 99%

A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions

Barbaud

Collet

Milpied

et al. 2013

British Journal of Dermatology

338

272

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SummaryBackground Drug patch tests (PTs) can reproduce delayed hypersensitivity to drugs and entail a moderate re-exposure of patients to offending drugs. Objectives To determine the value of PTs for identifying the responsible drug in severe cutaneous adverse drug reactions (SCARs) such as acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome ⁄toxic epidermal necrolysis (SJS ⁄TEN). Methods In a multicentre study, PTs were conducted on patients referred for DRESS, AGEP or SJS ⁄TEN within 1 year of their SCAR. All drugs administered in the 2 months prior to and the week following the onset of the SCAR were tested. Results Among the 134 patients included (48 male, 86 female; mean age 51AE7 years), positive drug PTs were obtained for 24 different drugs. These included positive tests for 64% (46 ⁄72) of patients with DRESS, 58% (26 ⁄45) of those with AGEP and 24% (4 ⁄17) of those with SJS ⁄TEN, with only one relapse of AGEP. The value of PTs depended on the type of drug and the type of SCAR (e.g. carbamazepine was positive in 11 ⁄13 DRESS cases but none of the five SJS ⁄TEN cases). PTs were frequently positive for beta lactams (22 cases), pristinamycin (11 cases) and in DRESS with pump proton inhibitors (five cases), but were usually negative for allopurinol and salazopyrin. Of 18 patients with DRESS, eight had virus reactivation and positive PTs. In DRESS, multiple drug reactivity was frequent (18% of cases), with patients remaining sensitized many years later. Conclusions PTs are useful and safe for identifying agents inducing SCAR.

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Section: Discussionmentioning

confidence: 99%

A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions

Barbaud

Collet

Milpied

et al. 2013

British Journal of Dermatology

338

272

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“…DRESS is reported to occur in approximately 1 : 1000 to 1 : 10000 of exposures to aromatic anticonvulsants, which are the most frequent cause (low). Drugs such as allopurinol, antibiotics, aspirin, and lamotrigin have been less frequently implicated in pediatric DRESS .…”

Section: Clinical Manifestations Of Drug Hypersensitivity In Childrenmentioning

confidence: 99%

Drug hypersensitivity in children: report from the pediatric task force of theEAACIDrug Allergy Interest Group

Gomes

Brockow

Kuyucu

et al. 2015

Allergy

254

336

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When questioned, about 10% of the parents report suspected hypersensitivity to at least one drug in their children. However, only a few of these reactions can be confirmed as allergic after a diagnostic workup. There is still a lack of knowledge on drug hypersensitivity (DH) epidemiology, clinical spectrum, and appropriate diagnostic methods particularly in children. Meanwhile, the tools used for DH management in adults are applied also for children. Whereas this appears generally acceptable, some aspects of DH and management differ with age. Most reactions in children are still attributed to betalactams. Some manifestations, such as nonsteroidal anti-inflammatory drug-associated angioedema and serum sicknesslike reactions, are more frequent among young patients as compared to adults. Risk factors such as viral infections are particularly frequent in children, making the diagnosis challenging. The practicability and validity of skin test and other diagnostic procedures need further assessment in children. This study presents an up-to-date review on epidemiology, clinical spectrum, diagnostic tools, and current management of DH in children. A new general algorithm for the study of these reactions in children is proposed. Data are presented focusing on reported differences between pediatric and adult patients, also identifying unmet needs to be addressed in further research.

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“…Research to confirm the reactivation of viral infections often bring about great diagnostic quality. The diagnostic markers include in high concentration 2’,5-oligoadenylate synthesis connected with the immunological disorder as a result of HHV-6 reactivation [36]. In order to verify the etiology of DRESS syndrome, the use patch tests and lymphocyte transformation tests are the acknowledged diagnostic methods used with drug hypersensitivity.…”

Section: Drug-induced Hypersensitivity Syndromementioning

confidence: 99%

Severe skin complications in patients treated with antidepressants: a literature review

Herstowska¹,

Komorowska²,

Cubała³

et al. 2014

pdia

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Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Adverse drug reactions of low risk include phenomena such as drug-induced rashes, phototoxic reactions, eczemas and urticarias, which appear most often when the medication is being introduced. Drug-induced skin reactions to psychotropic medication are usually associated with antiepileptic drugs. However, a significant role can be assigned to selective serotonin reuptake inhibitors. The aim of this paper is to review a spectrum of severe skin complications in patients treated with antidepressants with the indication of their clinical monitoring and management.

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Drug-induced hypersensitivity syndrome: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease

Cited by 25 publications

References 14 publications

A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions

A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions

Drug hypersensitivity in children: report from the pediatric task force of theEAACIDrug Allergy Interest Group

Severe skin complications in patients treated with antidepressants: a literature review

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