Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms with histologic features mimicking cutaneous pseudolymphoma

Sueki, Hirohiko; Sasaki, Miki; Kamiyama, Taisuke; Ohtoshi, Shinpei; Watanabe, Hideaki; Nakada, Tokio

doi:10.1111/1346-8138.12590

Cited by 7 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since CPLs may appear similar to cutaneous lymphomas, clinical information as well as molecular and histopathology data are important to make the final diagnosis. [34][35][36][37][38][39][40][41][42] The final diagnosis of CPL is supported by the absence of…”

Section: Discussionmentioning

confidence: 99%

“…Since CPLs may appear similar to cutaneous lymphomas, clinical information as well as molecular and histopathology data are important to make the final diagnosis 34–42 . The final diagnosis of CPL is supported by the absence of T‐cell receptor rearrangement, negative immunoglobulin heavy chain gene rearrangements, absence of plasma cell (mono‐) clonality, and polyclonal lambda and kappa light chains 3,33 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

et al. 2022

View full text Add to dashboard Cite

Drug‐induced cutaneous pseudolymphoma (CPL) is a common form of pseudolymphoma and there are numerous drugs associated with it. In this study, we performed a systematic review of the literature by searching PubMed/Medline and Embase databases to determine the most common drugs responsible for CPL and to define the demographic, clinical, histopathological and immunopathological characteristics of patients (updated on 30 December 2020). From 883 initially found articles, 56 studies (89 reported cases) were included. The mean age of patients was 54.4 ± 17.7 (ranging 8–86) years, and 46 (51.7%) were men. The median time interval between drug intake and CPL occurrence was 120 days (range 1–7300 days). The shortest median time interval between taking the drug and the onset of the disease was observed among patients taking antidepressants (60 days) (range 7–540) and the longest median time interval was observed in individuals using immunomodulators (300 days) (range 3–7300). The most‐reported drug categories causing CPL were anti‐hypertensives (17.9%), anticonvulsants (14.6%), monoclonal antibodies (13.4%) and antidepressants (11.2%). Moreover, the most common drugs were phenytoin (6.7%), amlodipine (5.6%), fluoxetine (5.6%) and carbamazepine (4.4%). Histopathological evaluation of 76 cases revealed 62 (81.5%) reports of T‐cell infiltrations. Furthermore, positive reports of CD4 (94.0%), CD8 (93.0%) and CD30 (87.5%) were noted. The lowest prevalence of CD30‐positive reports was observed among monoclonal antibodies. In conclusion, anti‐hypertensives, anti‐convulsants, monoclonal antibodies and anti‐depressants are the most common drugs responsible for CPL. It mostly presents in middle‐aged patients with almost no gender difference as pruritic papules, nodules and plaques.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

et al. 2022

View full text Add to dashboard Cite

show abstract

“…1 DRESS syndrome can occasionally mimic lymphoma, and, conversely, acute onset of lymphoma can mimic DRESS syndrome. 5,6 Although statins have not been reported to cause DRESS-like pseudolymphoma, they have been implicated in the causation of DRESS syndrome occasionally. 7 The most common drugs implicated in DRESS include sulfonamides, minocycline, dapsone, vancomycin, tyrosine kinase inhibitors, anticonvulsants (eg, lamotrigine, carbamazepine, phenytoin), febuxostat, and allopurinol.…”

Section: Discussionmentioning

confidence: 99%

“…1 An expanded T-cell population on bone marrow biopsy, seen in cutaneous T-cell lymphomas, can also occur in DRESS syndrome. 5 Neither patient was rechallenged with either medication due to the serious nature of the initial reactions.…”

Section: Discussionmentioning

confidence: 99%

Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma

et al. 2020

View full text Add to dashboard Cite

“…The minimum clinical criteria for the diagnosis include: (i) Exposure to drugs as stated earlier; (ii) Triad of fever, generalized rash and lymphadenopathy; and (iii) Improvement on stopping the offending drug [1][2][3]. Clinical features of drug-induced pseudolymphomas are not well known but generally may include generalized skin eruption, lymphadenopathy fever, arthralgia hepatosplenomegaly, eosinophilia and transaminitis [3][4][5][6].…”

Section: Case Reportmentioning

confidence: 99%

Lymphoma or Pseudolymphoma, that is the Question

Ahmed¹

2015

Clin Med Rev Case Rep

View full text Add to dashboard Cite

Drug-induced pseudolymphoma syndrome refers to a benign, druginduced lymphocytic infiltrate in the skin that mimics malignant lymphoma histologically, clinically, or both. At times, exposure to medication may result in cutaneous inflammatory patterns that resemble lymphoma. These pseudolymphomatous drug eruptions may resemble either T-cell or B-cell lymphomas.negative. Chest x-ray and Brain Computed tomography (CT) were unremarkable. CT neck, chest, abdomen and pelvis showed rightsided parapharyngeal abscess (Figure 1).Empiric intravenous antibiotics was started without improvement so incision and drainage were done and there was no

show abstract

Drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms with histologic features mimicking cutaneous pseudolymphoma

Cited by 7 publications

References 6 publications

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma

Lymphoma or Pseudolymphoma, that is the Question

Contact Info

Product

Resources

About